Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Curtis C. Hughey; Peter A. Crawford

doi:10.1016/j.cmet.2019.05.013

Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Curtis C. Hughey, Peter A. Crawford

Molecular Medicine

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.

Original language	English (US)
Pages (from-to)	1236-1238
Number of pages	3
Journal	Cell Metabolism
Volume	29
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2019.05.013
State	Published - Jun 4 2019

Bibliographical note

Funding Information:
This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases grant DK091538 (P.A.C.).

Publisher Copyright:
© 2019 Elsevier Inc.

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abstract = "Pyruvate carboxylase-mediated anaplerosis is a well-known regulator of gluconeogenesis. In this issue of Cell Metabolism, Cappel et al. (2019) show that pyruvate carboxylase action has far-reaching roles in metabolic homeostasis as it integrates glucose metabolism with tricarboxylic acid cycle flux, ureagenesis, redox potential, and defense against oxidative stress.",

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Pyruvate Carboxylase Wields a Double-Edged Metabolic Sword

Abstract

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