TY - JOUR
T1 - Quantitation of immunoglobulin-containing cells in the jejunal lamina propria in tropical sprue
AU - Malik, A. K.
AU - Mehta, S. K.
AU - Chandrashekhar, Y.
AU - Mahajan, A.
AU - Nanda, V.
AU - Kochhar, R.
PY - 1992/3
Y1 - 1992/3
N2 - Ten patients with tropical sprue (TS) and 10 with irritable bowel syndrome (IBS) as controls were studied to characterize the immunocytes in the jejunal mucosa. IgA cells numbered 516, 155 ± 48, 715 cells/mm3 in TS and 729, 308 ± 146, 011/mm3 in the IBS patients. IgG cell counts were 28, 885 ± 8, 081/mm3 in TS and 10, 615 ± 4, 100/mm3 in IBS; IgM counts were 170, 729 ± 25, 015/mm3 in TS and 169, 253 ± 45, 353/mm3 in IBS. A positive correlation was present between IgM-bearing plasma cells and corresponding serum immunoglobulins (r = +0.71; p < 0.05). No correlation was evident between the different immunocytes (IgA, IgG, and IgM) and the duration of illness, serum albumin, and tests for absorption of fat, B-12, and D-xylose (p > 0.05). The gut immunocytes expressed in absolute numbers were higher in our controls and TS patients than reported in Western populations.
AB - Ten patients with tropical sprue (TS) and 10 with irritable bowel syndrome (IBS) as controls were studied to characterize the immunocytes in the jejunal mucosa. IgA cells numbered 516, 155 ± 48, 715 cells/mm3 in TS and 729, 308 ± 146, 011/mm3 in the IBS patients. IgG cell counts were 28, 885 ± 8, 081/mm3 in TS and 10, 615 ± 4, 100/mm3 in IBS; IgM counts were 170, 729 ± 25, 015/mm3 in TS and 169, 253 ± 45, 353/mm3 in IBS. A positive correlation was present between IgM-bearing plasma cells and corresponding serum immunoglobulins (r = +0.71; p < 0.05). No correlation was evident between the different immunocytes (IgA, IgG, and IgM) and the duration of illness, serum albumin, and tests for absorption of fat, B-12, and D-xylose (p > 0.05). The gut immunocytes expressed in absolute numbers were higher in our controls and TS patients than reported in Western populations.
KW - Immunocytes
KW - Immunohistochemistry
KW - Jejunum
KW - Morphometry
KW - Tropical sprue
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U2 - 10.1097/00004836-199203000-00020
DO - 10.1097/00004836-199203000-00020
M3 - Article
C2 - 1556433
AN - SCOPUS:0026554841
SN - 0192-0790
VL - 14
SP - 163
EP - 166
JO - Journal of clinical gastroenterology
JF - Journal of clinical gastroenterology
IS - 2
ER -