TY - JOUR
T1 - Racial/ethnic and sex differences in young adult malignant brain tumor incidence by histologic type
AU - Monterroso, Pablo
AU - Moore, Kristin J.
AU - Sample, Jeannette M.
AU - Sorajja, Natali
AU - Domingues, Allison
AU - Williams, Lindsay A.
N1 - Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2022/2
Y1 - 2022/2
N2 - Background: Brain tumors are among the top four cancers in young adults. We assessed important windows of tumor development and examined the interplay of race/ethnicity, age, and sex in young adult brain tumor incidence. Methods: Using SEER 18 data (2000–2017), incidence rates were estimated by Poisson regression in individuals aged 20–39 years at diagnosis. Incidence rate ratios (IRR) and 95% confidence intervals (95% CI) were estimated by race/ethnicity, sex and age for 12 malignant histologies. Results: White incidence for all histologies was higher (White vs. Black IRR: 2.09, 95% CI: 1.94, 2.24; White vs Asian Pacific Islander IRR: 1.88, 95% CI: 1.75, 2.03; White vs Hispanic IRR: 1.70, 95% CI: 1.62, 1.78; White vs American Indian IRR: 1.40, 95% CI: 1.14, 1.73). Minority groups had higher lymphoma incidence (White vs Black IRR: 0.32, 95% CI: 0.25, 0.40, White vs Hispanic HR: 0.55, 95% CI: 0.44, 0.68). Males had higher incidence than females for all histologies (IRR: 1.36, 95% CI: 1.31, 1.41). Male rates were highest for lymphoma (male-to-female [MF] IRR: 2.00, 95% CI: 1.65, 2.42) and glioblastoma (MF IRR: 1.61, 95% CI: 1.48, 1.75). The male excess in incidence was similar by race/ethnicity and increased with age (20–24-year-old IRR: 1.18, 95% CI: 1.07, 1.29; 35–39-year-old IRR: 1.44, 95% CI: 1.35, 1.54). Conclusions: A White race and male incidence excess was observed among brain tumors. Impact: The male excess was similar by race/ethnicity and increased with age suggesting male sex may be an intrinsic risk factor for brain tumor development.
AB - Background: Brain tumors are among the top four cancers in young adults. We assessed important windows of tumor development and examined the interplay of race/ethnicity, age, and sex in young adult brain tumor incidence. Methods: Using SEER 18 data (2000–2017), incidence rates were estimated by Poisson regression in individuals aged 20–39 years at diagnosis. Incidence rate ratios (IRR) and 95% confidence intervals (95% CI) were estimated by race/ethnicity, sex and age for 12 malignant histologies. Results: White incidence for all histologies was higher (White vs. Black IRR: 2.09, 95% CI: 1.94, 2.24; White vs Asian Pacific Islander IRR: 1.88, 95% CI: 1.75, 2.03; White vs Hispanic IRR: 1.70, 95% CI: 1.62, 1.78; White vs American Indian IRR: 1.40, 95% CI: 1.14, 1.73). Minority groups had higher lymphoma incidence (White vs Black IRR: 0.32, 95% CI: 0.25, 0.40, White vs Hispanic HR: 0.55, 95% CI: 0.44, 0.68). Males had higher incidence than females for all histologies (IRR: 1.36, 95% CI: 1.31, 1.41). Male rates were highest for lymphoma (male-to-female [MF] IRR: 2.00, 95% CI: 1.65, 2.42) and glioblastoma (MF IRR: 1.61, 95% CI: 1.48, 1.75). The male excess in incidence was similar by race/ethnicity and increased with age (20–24-year-old IRR: 1.18, 95% CI: 1.07, 1.29; 35–39-year-old IRR: 1.44, 95% CI: 1.35, 1.54). Conclusions: A White race and male incidence excess was observed among brain tumors. Impact: The male excess was similar by race/ethnicity and increased with age suggesting male sex may be an intrinsic risk factor for brain tumor development.
KW - Incidence
KW - Malignant brain tumors
KW - Racial disparities
KW - Sex differences
KW - Young adults
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U2 - 10.1016/j.canep.2021.102078
DO - 10.1016/j.canep.2021.102078
M3 - Article
C2 - 34896933
AN - SCOPUS:85120935140
SN - 1877-7821
VL - 76
JO - Cancer Epidemiology
JF - Cancer Epidemiology
M1 - 102078
ER -