Abstract
(formula presented) An efficient, concise approach to the macrolide core of the cryptophycins, potent antimitotic agents, has been achieved. The reaction sequence features a novel macrolactonization utilizing a reactive acyl-β-lactam intermediate that incorporates the β-amino acid moiety within the 16-membered macrolide core. This highly modular approach, which allows for multiple alterations throughout the structure, was successfully applied to the total synthesis of cryptophycin-24.
Original language | English (US) |
---|---|
Pages (from-to) | 1813-1815 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 3 |
Issue number | 12 |
DOIs | |
State | Published - Jun 14 2001 |