Rapid MR imaging of cryoprotectant permeation in an engineered dermal replacement

N. P. Bidault; B. E. Hammer; A. Hubel

doi:10.1006/cryo.1999.2216

Rapid MR imaging of cryoprotectant permeation in an engineered dermal replacement

N. P. Bidault, B. E. Hammer, A. Hubel

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Magnetic resonance (MR) imaging is a powerful technique for monitoring the permeation of cryoprotective agents (CPAs) inside tissues. However, the techniques published until now suffer from inherently long imaging times, limiting the application of these techniques to slow diffusion processes and large CPA concentrations. In this study, we present a rapid MR imaging technique based on a CHESS-FLASH scheme combined with Keyhole image acquisition. This technique can image the fast permeation of Me₂SO solutions into freeze-dried artificial dermal replacements for concentrations down to 10% v/v. Special attention is given to evaluating the technique for quantitative analysis. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	13-26
Number of pages	14
Journal	Cryobiology
Volume	40
Issue number	1
DOIs	https://doi.org/10.1006/cryo.1999.2216
State	Published - Feb 2000

Bibliographical note

Funding Information:
Received October 20, 1998; accepted October 26, 1999. This research was funded in part by grants from the Minnesota Medical Foundation and the National Science Foundation (BED 9410428).

Keywords

Artificial tissue
MeSO
Rapid MR imaging

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abstract = "Magnetic resonance (MR) imaging is a powerful technique for monitoring the permeation of cryoprotective agents (CPAs) inside tissues. However, the techniques published until now suffer from inherently long imaging times, limiting the application of these techniques to slow diffusion processes and large CPA concentrations. In this study, we present a rapid MR imaging technique based on a CHESS-FLASH scheme combined with Keyhole image acquisition. This technique can image the fast permeation of Me2SO solutions into freeze-dried artificial dermal replacements for concentrations down to 10% v/v. Special attention is given to evaluating the technique for quantitative analysis. (C) 2000 Academic Press.",

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AB - Magnetic resonance (MR) imaging is a powerful technique for monitoring the permeation of cryoprotective agents (CPAs) inside tissues. However, the techniques published until now suffer from inherently long imaging times, limiting the application of these techniques to slow diffusion processes and large CPA concentrations. In this study, we present a rapid MR imaging technique based on a CHESS-FLASH scheme combined with Keyhole image acquisition. This technique can image the fast permeation of Me2SO solutions into freeze-dried artificial dermal replacements for concentrations down to 10% v/v. Special attention is given to evaluating the technique for quantitative analysis. (C) 2000 Academic Press.

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Rapid MR imaging of cryoprotectant permeation in an engineered dermal replacement

Abstract

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Keywords

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