Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma

Philippe F. Nyembo; Keith E. Eidman; Mengistu Simegn; Andrew W. Shaffer; Gautam R. Shroff

doi:10.1016/j.jaccas.2022.07.034

Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma

Philippe F. Nyembo, Keith E. Eidman, Mengistu Simegn, Andrew W. Shaffer, Gautam R. Shroff

Surgery

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Warfarin is the only approved anticoagulant after mechanical valve replacement, but it is a well described risk factor for calciphylaxis among patients with end-stage kidney disease. Our patient with end-stage kidney disease rapidly developed calciphylaxis after dual mechanical valve replacement in association with warfarin initiation, posing significant challenges in clinical management and a fatal outcome. (Level of Difficulty: Intermediate.)

Original language	English (US)
Pages (from-to)	1319-1323
Number of pages	5
Journal	JACC: Case Reports
Volume	4
Issue number	19
DOIs	https://doi.org/10.1016/j.jaccas.2022.07.034
State	Published - Oct 5 2022

Bibliographical note

Publisher Copyright:
© 2022 The Authors

Keywords

anticoagulation
disorders of calcium disease
thrombosis
valve replacement

PubMed: MeSH publication types

Case Reports

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.jaccas.2022.07.034

OpenUrl availability

Full text

Cite this

@article{dce0e54237144a26a5117a146cd2f33f,

title = "Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma",

abstract = "Warfarin is the only approved anticoagulant after mechanical valve replacement, but it is a well described risk factor for calciphylaxis among patients with end-stage kidney disease. Our patient with end-stage kidney disease rapidly developed calciphylaxis after dual mechanical valve replacement in association with warfarin initiation, posing significant challenges in clinical management and a fatal outcome. (Level of Difficulty: Intermediate.)",

keywords = "anticoagulation, disorders of calcium disease, thrombosis, valve replacement",

author = "Nyembo, {Philippe F.} and Eidman, {Keith E.} and Mengistu Simegn and Shaffer, {Andrew W.} and Shroff, {Gautam R.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = oct,

day = "5",

doi = "10.1016/j.jaccas.2022.07.034",

language = "English (US)",

volume = "4",

pages = "1319--1323",

journal = "JACC: Case Reports",

issn = "2666-0849",

publisher = "Elsevier Inc.",

number = "19",

}

TY - JOUR

T1 - Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement

T2 - An Anticoagulation Dilemma

AU - Nyembo, Philippe F.

AU - Eidman, Keith E.

AU - Simegn, Mengistu

AU - Shaffer, Andrew W.

AU - Shroff, Gautam R.

PY - 2022/10/5

Y1 - 2022/10/5

N2 - Warfarin is the only approved anticoagulant after mechanical valve replacement, but it is a well described risk factor for calciphylaxis among patients with end-stage kidney disease. Our patient with end-stage kidney disease rapidly developed calciphylaxis after dual mechanical valve replacement in association with warfarin initiation, posing significant challenges in clinical management and a fatal outcome. (Level of Difficulty: Intermediate.)

AB - Warfarin is the only approved anticoagulant after mechanical valve replacement, but it is a well described risk factor for calciphylaxis among patients with end-stage kidney disease. Our patient with end-stage kidney disease rapidly developed calciphylaxis after dual mechanical valve replacement in association with warfarin initiation, posing significant challenges in clinical management and a fatal outcome. (Level of Difficulty: Intermediate.)

KW - anticoagulation

KW - disorders of calcium disease

KW - thrombosis

KW - valve replacement

UR - http://www.scopus.com/inward/record.url?scp=85138826251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85138826251&partnerID=8YFLogxK

U2 - 10.1016/j.jaccas.2022.07.034

DO - 10.1016/j.jaccas.2022.07.034

M3 - Article

C2 - 36406917

AN - SCOPUS:85138826251

SN - 2666-0849

VL - 4

SP - 1319

EP - 1323

JO - JACC: Case Reports

JF - JACC: Case Reports

IS - 19

ER -

Rapidly Progressive and Catastrophic Calciphylaxis After Mechanical Valve Replacement: An Anticoagulation Dilemma

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this