Rate of force production and relaxation is impaired in patients with focal hand dystonia

Janey Prodoehl; Colum D. MacKinnon; Cynthia L. Comella; Daniel M. Corcos

doi:10.1016/j.parkreldis.2006.01.008

Rate of force production and relaxation is impaired in patients with focal hand dystonia

Janey Prodoehl, Colum D. MacKinnon, Cynthia L. Comella, Daniel M. Corcos

Neurology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

One factor, which may contribute to slowed movement in dystonia, is impairment in controlling the voluntary rate of motor output. This study examined the ability of patients with focal hand dystonia to rapidly turn force on and off at the wrist and elbow joints. Dystonic patients were slower than controls in rapidly turning on force from rest at both joints, passively relaxing force and rapidly reversing force output from a steady-state flexion contraction. Adding a preload did not improve the ability of dystonic subjects to rapidly turn on force. These results support the idea that dystonia is a disorder of impaired motor cortical activation, possibly due to basal ganglia dysfunction.

Original language	English (US)
Pages (from-to)	363-371
Number of pages	9
Journal	Parkinsonism and Related Disorders
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/j.parkreldis.2006.01.008
State	Published - Sep 2006

Bibliographical note

Funding Information:
We would like to thank the staff at the Section for Movement Disorders in the Department of Neurological Sciences at Rush University Medical Center and Dr. Tanya Simuni in the Department of Neurology at Northwestern Memorial Hospital for their assistance in patient recruitment. Also, we thank Dr. Annette Weis-McNulty and Ms. Emily Gilley for their assistance with some aspects of data collection. This study was supported in part by the National Institutes of Health Grants AR33189, NS21827, and NS40902.

Keywords

Basal ganglia
Isometric
Motor control
Writer's cramp

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title = "Rate of force production and relaxation is impaired in patients with focal hand dystonia",

abstract = "One factor, which may contribute to slowed movement in dystonia, is impairment in controlling the voluntary rate of motor output. This study examined the ability of patients with focal hand dystonia to rapidly turn force on and off at the wrist and elbow joints. Dystonic patients were slower than controls in rapidly turning on force from rest at both joints, passively relaxing force and rapidly reversing force output from a steady-state flexion contraction. Adding a preload did not improve the ability of dystonic subjects to rapidly turn on force. These results support the idea that dystonia is a disorder of impaired motor cortical activation, possibly due to basal ganglia dysfunction.",

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author = "Janey Prodoehl and MacKinnon, {Colum D.} and Comella, {Cynthia L.} and Corcos, {Daniel M.}",

note = "Funding Information: We would like to thank the staff at the Section for Movement Disorders in the Department of Neurological Sciences at Rush University Medical Center and Dr. Tanya Simuni in the Department of Neurology at Northwestern Memorial Hospital for their assistance in patient recruitment. Also, we thank Dr. Annette Weis-McNulty and Ms. Emily Gilley for their assistance with some aspects of data collection. This study was supported in part by the National Institutes of Health Grants AR33189, NS21827, and NS40902.",

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AU - Prodoehl, Janey

AU - MacKinnon, Colum D.

AU - Comella, Cynthia L.

AU - Corcos, Daniel M.

N1 - Funding Information: We would like to thank the staff at the Section for Movement Disorders in the Department of Neurological Sciences at Rush University Medical Center and Dr. Tanya Simuni in the Department of Neurology at Northwestern Memorial Hospital for their assistance in patient recruitment. Also, we thank Dr. Annette Weis-McNulty and Ms. Emily Gilley for their assistance with some aspects of data collection. This study was supported in part by the National Institutes of Health Grants AR33189, NS21827, and NS40902.

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N2 - One factor, which may contribute to slowed movement in dystonia, is impairment in controlling the voluntary rate of motor output. This study examined the ability of patients with focal hand dystonia to rapidly turn force on and off at the wrist and elbow joints. Dystonic patients were slower than controls in rapidly turning on force from rest at both joints, passively relaxing force and rapidly reversing force output from a steady-state flexion contraction. Adding a preload did not improve the ability of dystonic subjects to rapidly turn on force. These results support the idea that dystonia is a disorder of impaired motor cortical activation, possibly due to basal ganglia dysfunction.

AB - One factor, which may contribute to slowed movement in dystonia, is impairment in controlling the voluntary rate of motor output. This study examined the ability of patients with focal hand dystonia to rapidly turn force on and off at the wrist and elbow joints. Dystonic patients were slower than controls in rapidly turning on force from rest at both joints, passively relaxing force and rapidly reversing force output from a steady-state flexion contraction. Adding a preload did not improve the ability of dystonic subjects to rapidly turn on force. These results support the idea that dystonia is a disorder of impaired motor cortical activation, possibly due to basal ganglia dysfunction.

KW - Basal ganglia

KW - Isometric

KW - Motor control

KW - Writer's cramp

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JO - Parkinsonism and Related Disorders

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ER -

Rate of force production and relaxation is impaired in patients with focal hand dystonia

Abstract

Bibliographical note

Keywords

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