Abstract
(Figure Presented) The concentration of reactive metal hydride (Met-H) reducing agents can be determined (in ≤20 min) using No-D NMR spectroscopy. The method involves (i) reacting Met-H with an excess of p-methoxybenzaldehyde, (ii) quenching with excess acetic acid, (iii) recording the No-D NMR spectrum of this homogeneous mixture, and (iv) deducing the concentration of Met-H from the % conversion (as measured by integration). By a conceptually related method, the titer of the basic alkali metal hydrides KH and NaH can also be determined.
Original language | English (US) |
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Pages (from-to) | 2205-2208 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 7 |
Issue number | 11 |
DOIs | |
State | Published - May 26 2005 |