Reelin, GABA, FMRP, and Autism

Timothy D. Folsom; S. Hossein Fatemi

doi:10.1007/978-1-4939-2190-4_16

Reelin, GABA, FMRP, and Autism

Timothy D. Folsom, S. Hossein Fatemi

Psychiatry & Behavioral Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Autism is a heterogeneous neurodevelopmental disorder. The etiology of autism remains unknown although both genetic and environmental factors are likely to be involved. These factors disrupt the course of normal brain development from the cellular to the gross anatomical levels. The Reelin, gamma-aminobutyric acid (GABA), and fragile X mental retardation protein (FMRP)—metabotropic glutamate receptor 5 (mGluR5) signaling systems play important roles during the development of the nervous system. Disruption of these pathways is likely to lead to altered synaptic transmission and, ultimately, the cognitive and behavioral deficits associated with autism. This chapter describes each of these signaling systems and summarizes the current evidence that link them to autism. Therapies that target molecules in these signaling systems may provide new means of treating the core symptoms of autism.

Original language	English (US)
Title of host publication	Contemporary Clinical Neuroscience
Publisher	Springer Nature
Pages	337-359
Number of pages	23
DOIs	https://doi.org/10.1007/978-1-4939-2190-4_16
State	Published - 2015

Publication series

Name	Contemporary Clinical Neuroscience
ISSN (Print)	2627-535X
ISSN (Electronic)	2627-5341

Bibliographical note

Funding Information:
Acknowledgments Grant support from NICHD (R01HD052074), NIMH (R01MH086000), the Bernstein Endowed Chair in Adult Psychiatry, and the Ewald Bipolar Disease Research Fund to SHF is gratefully acknowledged. Dr. Fatemi currently holds United States patents for Reelin as

Publisher Copyright:
© 2015, Springer Science+Business Media New York.

Keywords

Brain
FMRP
GABA
Reelin
mGluR5

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Reelin, GABA, FMRP, and Autism

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