TY - JOUR
T1 - Regenerative biology
T2 - A historical perspective and modern applications
AU - Weaver, Cyprian V.
AU - Garry, Daniel J.
PY - 2008/1
Y1 - 2008/1
N2 - Chronic diseases are both common and deadly. Due to the limitations of conventional therapies for chronic diseases such as advanced heart failure and diabetes mellitus, recent interest has been directed towards regenerative redicine. In this review, we examine the history of regenerative biology and emphasize the dynamic and multidisciplinary growth of this field. We highlight the spectrum of adult tissues that have a remarkable regenerative capacity (i.e., skeletal muscle) versus those that have a more limited regenerative capacity (i.e., heart). We further emphasize the use of relevant contemporary models for the study of regenerative biology (i.e., pancreatic regeneration), which highlight both the challenges for this field of study and the potential for regenerative medicine, including the use of cell-baseb strategies, to revolutionize medical therapies for chronic diseases.
AB - Chronic diseases are both common and deadly. Due to the limitations of conventional therapies for chronic diseases such as advanced heart failure and diabetes mellitus, recent interest has been directed towards regenerative redicine. In this review, we examine the history of regenerative biology and emphasize the dynamic and multidisciplinary growth of this field. We highlight the spectrum of adult tissues that have a remarkable regenerative capacity (i.e., skeletal muscle) versus those that have a more limited regenerative capacity (i.e., heart). We further emphasize the use of relevant contemporary models for the study of regenerative biology (i.e., pancreatic regeneration), which highlight both the challenges for this field of study and the potential for regenerative medicine, including the use of cell-baseb strategies, to revolutionize medical therapies for chronic diseases.
KW - Cardiac regeneration
KW - History of regeneration
KW - Pancreas regeneration
KW - Skeletal muscle regeneration
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=38449115312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38449115312&partnerID=8YFLogxK
U2 - 10.2217/17460751.3.1.63
DO - 10.2217/17460751.3.1.63
M3 - Review article
C2 - 18154463
AN - SCOPUS:38449115312
SN - 1746-0751
VL - 3
SP - 63
EP - 82
JO - Regenerative Medicine
JF - Regenerative Medicine
IS - 1
ER -
