TY - JOUR
T1 - Regulation of protein degradation by O-GlcNAcylation
T2 - Crosstalk with ubiquitination
AU - Ruan, Hai Bin
AU - Nie, Yongzhan
AU - Yang, Xiaoyong
PY - 2013/12
Y1 - 2013/12
N2 - The post-translational modification of intracellular proteins by O-linked N-acetylglucosamine (O-GlcNAc) regulates essential cellular processes such as signal transduction, transcription, translation, and protein degradation. Misfolded, damaged, and unwanted proteins are tagged with a chain of ubiquitin moieties for degradation by the proteasome, which is critical for cellular homeostasis. In this review, we summarize the current knowledge of the interplay between O-GlcNAcylation and ubiquitination in the control of protein degradation. Understanding the mechanisms of action of O-GlcNAcylation in the ubiquitin-proteosome system shall facilitate the development of therapeutics for human diseases such as cancer, metabolic syndrome, and neurodegenerative diseases.
AB - The post-translational modification of intracellular proteins by O-linked N-acetylglucosamine (O-GlcNAc) regulates essential cellular processes such as signal transduction, transcription, translation, and protein degradation. Misfolded, damaged, and unwanted proteins are tagged with a chain of ubiquitin moieties for degradation by the proteasome, which is critical for cellular homeostasis. In this review, we summarize the current knowledge of the interplay between O-GlcNAcylation and ubiquitination in the control of protein degradation. Understanding the mechanisms of action of O-GlcNAcylation in the ubiquitin-proteosome system shall facilitate the development of therapeutics for human diseases such as cancer, metabolic syndrome, and neurodegenerative diseases.
UR - http://www.scopus.com/inward/record.url?scp=84890731711&partnerID=8YFLogxK
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U2 - 10.1074/mcp.R113.029751
DO - 10.1074/mcp.R113.029751
M3 - Review article
C2 - 23824911
AN - SCOPUS:84890731711
SN - 1535-9476
VL - 12
SP - 3489
EP - 3497
JO - Molecular and Cellular Proteomics
JF - Molecular and Cellular Proteomics
IS - 12
ER -