TY - JOUR
T1 - Regulatory roles of vertebrate Nocturnin
T2 - insights and remaining mysteries
AU - Hughes, Kelsey L.
AU - Abshire, Elizabeth T.
AU - Goldstrohm, Aaron C.
N1 - Publisher Copyright:
© 2018, © 2018 The Author(s). Published by Taylor & Francis.
PY - 2018/10/3
Y1 - 2018/10/3
N2 - Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3′ poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin’s involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin’s regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.
AB - Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3′ poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin’s involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin’s regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.
KW - NOCT
KW - Nocturnin
KW - RNA decay
KW - deadenylase
KW - translational control
UR - http://www.scopus.com/inward/record.url?scp=85056519497&partnerID=8YFLogxK
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U2 - 10.1080/15476286.2018.1526541
DO - 10.1080/15476286.2018.1526541
M3 - Review article
C2 - 30257600
AN - SCOPUS:85056519497
SN - 1547-6286
VL - 15
SP - 1255
EP - 1267
JO - RNA Biology
JF - RNA Biology
IS - 10
ER -