Renal transplantation in patients with alport syndrome: Patient selection, outcomes, and donor evaluation

Clifford E. Kashtan

doi:10.2147/IJNRD.S150539

Renal transplantation in patients with alport syndrome: Patient selection, outcomes, and donor evaluation

Clifford E. Kashtan

Pediatrics - Nephrology

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm.

Original language	English (US)
Pages (from-to)	267-270
Number of pages	4
Journal	International Journal of Nephrology and Renovascular Disease
Volume	11
DOIs	https://doi.org/10.2147/IJNRD.S150539
State	Published - 2018

Bibliographical note

Funding Information:
NCT00481130), which receives financial support from the Alport Syndrome Foundation (alportsyndrome.org) and the Schuman and Pedersen families. Dr Kashtan is a site investigator for the CARDINAL trial (NCT03019185) sponsored by Reata Pharmaceuticals, Inc. and the HERA trial (NCT02855268) sponsored by Regulus Therapeutics, Inc. Dr Kashtan has also recently received research support from the Novartis Institute for Biomedical Research (NCT03074357).

Publisher Copyright:
© 2018 Kashtan.

Keywords

Alport syndrome
Collagen IV
Kidney transplantation
Posttransplant anti-GBM Nephritis

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abstract = "Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm.",

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Renal transplantation in patients with alport syndrome: Patient selection, outcomes, and donor evaluation

Abstract

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