Abstract
DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 168-178 |
| Number of pages | 11 |
| Journal | Current Opinion in Cell Biology |
| Volume | 40 |
| DOIs | |
| State | Published - Jun 1 2016 |
| Externally published | Yes |
Bibliographical note
Funding Information:We would like to thank C. Trevilla-Garcia for critical reading of the manuscript and Karen Reddy for helpful discussions. This work was supported by National Institutes of Health (NIH) grants GM083337 and GM085354 (D.M.G.).
Publisher Copyright:
© 2016 Elsevier Ltd.