TY - CHAP
T1 - Respiratory bacterial vaccines
AU - Janoff, Edward N.
AU - Briles, David E.
AU - Rubins, Jeff B
PY - 2005
Y1 - 2005
N2 - This chapter reviews the vaccines against four prominent and prototypical respiratory mucosal bacteria-. Corynebacterium diphtheriae, Bordetella pertussis, Haemophilus influenzae, and Streptococcus pneumonia. The chapterhighlights the virulence mechanisms involved in the mucosal infections that form the basis for these immunogenic and clinically efficacious vaccines. S. pneumoniae is the single most common cause of potentially preventable respiratory bacterial disease in children and adults worldwide. Systemic immunization is effective in preventing localized respiratory bacterial infections with C. diphtheriae and B. pertussis and both invasive infections and colonization with H. influenzae. Diphtheria vaccine is directed towards a single but pivotal disease-related toxin. The H. influenzae vaccine is directed towards a single prominent virulence mechanism-the polysaccharide capsule, but towards only one capsule (type b) on a complement-lysis-sensitive gram-negative organism. In contrast, S. pneumoniae has no preeminent single disease-determining toxin, and the efficient killing of this gram-positive complement lysis-resistant organism requires the combination of complement, phagocytic cells, and specific antibody to many capsular polysaccharides.
AB - This chapter reviews the vaccines against four prominent and prototypical respiratory mucosal bacteria-. Corynebacterium diphtheriae, Bordetella pertussis, Haemophilus influenzae, and Streptococcus pneumonia. The chapterhighlights the virulence mechanisms involved in the mucosal infections that form the basis for these immunogenic and clinically efficacious vaccines. S. pneumoniae is the single most common cause of potentially preventable respiratory bacterial disease in children and adults worldwide. Systemic immunization is effective in preventing localized respiratory bacterial infections with C. diphtheriae and B. pertussis and both invasive infections and colonization with H. influenzae. Diphtheria vaccine is directed towards a single but pivotal disease-related toxin. The H. influenzae vaccine is directed towards a single prominent virulence mechanism-the polysaccharide capsule, but towards only one capsule (type b) on a complement-lysis-sensitive gram-negative organism. In contrast, S. pneumoniae has no preeminent single disease-determining toxin, and the efficient killing of this gram-positive complement lysis-resistant organism requires the combination of complement, phagocytic cells, and specific antibody to many capsular polysaccharides.
UR - http://www.scopus.com/inward/record.url?scp=84882845653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882845653&partnerID=8YFLogxK
U2 - 10.1016/B978-012491543-5/50054-1
DO - 10.1016/B978-012491543-5/50054-1
M3 - Chapter
AN - SCOPUS:84882845653
SN - 9780124915435
SP - 905
EP - 921
BT - Mucosal Immunology, Two-Volume Set
PB - Elsevier Inc.
ER -