RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5

A. M. Api; D. Belsito; D. Botelho; D. Browne; M. Bruze; G. A. Burton; J. Buschmann; P. Calow; M. L. Dagli; M. Date; W. Dekant; C. Deodhar; A. D. Fryer; K. Joshi; S. La Cava; A. Lapczynski; D. C. Liebler; D. O'Brien; R. Parakhia; A. Patel; T. M. Penning; G. Ritacco; J. Romine; D. Salvito; T. W. Schultz; I. G. Sipes; Y. Thakkar; S. Tsang; J. Wahler

doi:10.1016/j.fct.2017.05.066

RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5

A. M. Api, D. Belsito, D. Botelho, D. Browne, M. Bruze, G. A. Burton, J. Buschmann, P. Calow, M. L. Dagli, M. Date, W. Dekant, C. Deodhar, A. D. Fryer, K. Joshi, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, R. Parakhia, A. PatelT. M. Penning, G. Ritacco, J. Romine, D. Salvito, T. W. Schultz, I. G. Sipes, Y. Thakkar, S. Tsang, J. Wahler

Research output: Contribution to journal › Short survey › peer-review

Abstract

The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra.

Original language	English (US)
Pages (from-to)	S234-S241
Journal	Food and Chemical Toxicology
Volume	110
DOIs	https://doi.org/10.1016/j.fct.2017.05.066
State	Published - Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

Developmental and reproductive toxicity
Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose
Skin sensitization

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Api, A. M., Belsito, D., Botelho, D., Browne, D., Bruze, M., Burton, G. A., Buschmann, J., Calow, P., Dagli, M. L., Date, M., Dekant, W., Deodhar, C., Fryer, A. D., Joshi, K., La Cava, S., Lapczynski, A., Liebler, D. C., O'Brien, D., Parakhia, R., ... Wahler, J. (2017). RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5. Food and Chemical Toxicology, 110, S234-S241. https://doi.org/10.1016/j.fct.2017.05.066

Api, AM, Belsito, D, Botelho, D, Browne, D, Bruze, M, Burton, GA, Buschmann, J, Calow, P, Dagli, ML, Date, M, Dekant, W, Deodhar, C, Fryer, AD, Joshi, K, La Cava, S, Lapczynski, A, Liebler, DC, O'Brien, D, Parakhia, R, Patel, A, Penning, TM, Ritacco, G, Romine, J, Salvito, D, Schultz, TW, Sipes, IG, Thakkar, Y, Tsang, S & Wahler, J 2017, 'RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5', Food and Chemical Toxicology, vol. 110, pp. S234-S241. https://doi.org/10.1016/j.fct.2017.05.066

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abstract = "The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra.",

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AU - Api, A. M.

AU - Belsito, D.

AU - Botelho, D.

AU - Browne, D.

AU - Bruze, M.

AU - Burton, G. A.

AU - Buschmann, J.

AU - Calow, P.

AU - Dagli, M. L.

AU - Date, M.

AU - Dekant, W.

AU - Deodhar, C.

AU - Fryer, A. D.

AU - Joshi, K.

AU - La Cava, S.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - O'Brien, D.

AU - Parakhia, R.

AU - Patel, A.

AU - Penning, T. M.

AU - Ritacco, G.

AU - Romine, J.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Sipes, I. G.

AU - Thakkar, Y.

AU - Tsang, S.

AU - Wahler, J.

PY - 2017/12

Y1 - 2017/12

N2 - The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra.

AB - The use of this material under current conditions is supported by existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data show that this material is not genotoxic. Data from the suitable read across analog isoamyl acetate (CAS# 123-92-2) show that this material does not have skin sensitization potential. The reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03 mg/kg/day and 1.4 mg/day, respectively). The repeated dose and developmental endpoint was completed using data on the target material, which provided a MOE > 100. The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra.

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KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

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RIFM fragrance ingredient safety assessment, acetic acid, C7-9-branched alkyl esters, C8-rich, CAS Registry Number 108419-32-5

Abstract

Bibliographical note

Keywords

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