RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

A. M. Api; D. Belsito; S. Bhatia; M. Bruze; P. Calow; M. L. Dagli; W. Dekant; A. D. Fryer; L. Kromidas; S. La Cava; A. Lapczynski; D. C. Liebler; D. O'Brien; R. Parakhia; T. M. Penning; V. T. Politano; G. Ritacco; D. Salvito; T. W. Schultz; J. Shen; I. G. Sipes; B. Wall; D. K. Wilcox

doi:10.1016/j.fct.2016.10.029

RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

A. M. Api, D. Belsito, S. Bhatia, M. Bruze, P. Calow, M. L. Dagli, W. Dekant, A. D. Fryer, L. Kromidas, S. La Cava, A. Lapczynski, D. C. Liebler, D. O'Brien, R. Parakhia, T. M. Penning, V. T. Politano, G. Ritacco, D. Salvito, T. W. Schultz, J. ShenI. G. Sipes, B. Wall, D. K. Wilcox

Research output: Contribution to journal › Short survey › peer-review

Abstract

This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

Original language	English (US)
Pages (from-to)	S1-S8
Journal	Food and Chemical Toxicology
Volume	110
DOIs	https://doi.org/10.1016/j.fct.2016.10.029
State	Published - Dec 2017

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Ltd

Keywords

Developmental and reproductive toxicity
Environmental safety
Genotoxicity
Local respiratory toxicity
Phototoxicity/photoallergenicity
Repeated dose
Skin sensitization

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Api, A. M., Belsito, D., Bhatia, S., Bruze, M., Calow, P., Dagli, M. L., Dekant, W., Fryer, A. D., Kromidas, L., La Cava, S., Lapczynski, A., Liebler, D. C., O'Brien, D., Parakhia, R., Penning, T. M., Politano, V. T., Ritacco, G., Salvito, D., Schultz, T. W., ... Wilcox, D. K. (2017). RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9. Food and Chemical Toxicology, 110, S1-S8. https://doi.org/10.1016/j.fct.2016.10.029

Api, AM, Belsito, D, Bhatia, S, Bruze, M, Calow, P, Dagli, ML, Dekant, W, Fryer, AD, Kromidas, L, La Cava, S, Lapczynski, A, Liebler, DC, O'Brien, D, Parakhia, R, Penning, TM, Politano, VT, Ritacco, G, Salvito, D, Schultz, TW, Shen, J, Sipes, IG, Wall, B & Wilcox, DK 2017, 'RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9', Food and Chemical Toxicology, vol. 110, pp. S1-S8. https://doi.org/10.1016/j.fct.2016.10.029

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abstract = "This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.",

keywords = "Developmental and reproductive toxicity, Environmental safety, Genotoxicity, Local respiratory toxicity, Phototoxicity/photoallergenicity, Repeated dose, Skin sensitization",

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year = "2017",

month = dec,

doi = "10.1016/j.fct.2016.10.029",

language = "English (US)",

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T1 - RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

AU - Api, A. M.

AU - Belsito, D.

AU - Bhatia, S.

AU - Bruze, M.

AU - Calow, P.

AU - Dagli, M. L.

AU - Dekant, W.

AU - Fryer, A. D.

AU - Kromidas, L.

AU - La Cava, S.

AU - Lapczynski, A.

AU - Liebler, D. C.

AU - O'Brien, D.

AU - Parakhia, R.

AU - Penning, T. M.

AU - Politano, V. T.

AU - Ritacco, G.

AU - Salvito, D.

AU - Schultz, T. W.

AU - Shen, J.

AU - Sipes, I. G.

AU - Wall, B.

AU - Wilcox, D. K.

PY - 2017/12

Y1 - 2017/12

N2 - This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

AB - This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization potential, as well as, environmental safety. Data from the suitable read across analog isobornyl acetate (CAS # 125-12-2) show that this material is not genotoxic, provided a MOE > 100 for the repeated dose, developmental and reproductive endpoints, and does not have skin sensitization potential. The local respiratory toxicity endpoint was completed using the TTC (threshold of Toxicological Concern) for a Cramer Class II material (0.47 mg/day). The phototoxicity/photoallergenicity endpoint was completed based on suitable UV spectra. The environmental endpoint was completed as described in the RIFM Framework.

KW - Developmental and reproductive toxicity

KW - Environmental safety

KW - Genotoxicity

KW - Local respiratory toxicity

KW - Phototoxicity/photoallergenicity

KW - Repeated dose

KW - Skin sensitization

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SN - 0278-6915

VL - 110

SP - S1-S8

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JF - Food and Chemical Toxicology

ER -

RIFM fragrance ingredient safety assessment, isobornyl isovalerate, CAS registry number 7779-73-9

Abstract

Bibliographical note

Keywords

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