TY - JOUR
T1 - Risk factors for intracerebral hemorrhage in a pooled prospective study
AU - Sturgeon, Jared D.
AU - Folsom, Aaron R.
AU - Longstreth, W. T.
AU - Shahar, Eyal
AU - Rosamond, Wayne D.
AU - Cushman, Mary
PY - 2007/10
Y1 - 2007/10
N2 - BACKGROUND AND PURPOSE - Few prospective studies have reported risk factors for intracerebral hemorrhage (ICH), and results are inconsistent. We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS). METHODS - The ARIC cohort was recruited in 1987 to 1989 and involves 15 792 men and women, aged 45 to 64 years at baseline, sampled from 4 US communities. The CHS cohort was recruited in 1989 to 1993 and involves 5888 men and women, aged 65 or over at baseline, sampled from 4 US communities. Baseline measurements included many potential vascular risk factors. The cohorts were followed for incident stroke events. RESULTS - Over 263 489 person-years of follow-up, 135 incident ICH events occurred. In a multivariable model, age, African-American ethnicity (versus Whites), and hypertension were positively associated with incident ICH, whereas low-density lipoprotein cholesterol and triglycerides were inversely related to incident ICH. Participants with systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110 mm Hg had 5.55 (95% CI 3.07 to 10.0) times the rate of ICH as nonhypertensives. Sex, smoking, alcohol intake, body mass index, waist-to-hip ratio, waist circumference, and diabetes were not related to ICH. CONCLUSIONS - In this pooled cohort the risk factors for ICH were older age, African-American ethnicity, hypertension, lower LDL-C, and lower triglycerides.
AB - BACKGROUND AND PURPOSE - Few prospective studies have reported risk factors for intracerebral hemorrhage (ICH), and results are inconsistent. We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS). METHODS - The ARIC cohort was recruited in 1987 to 1989 and involves 15 792 men and women, aged 45 to 64 years at baseline, sampled from 4 US communities. The CHS cohort was recruited in 1989 to 1993 and involves 5888 men and women, aged 65 or over at baseline, sampled from 4 US communities. Baseline measurements included many potential vascular risk factors. The cohorts were followed for incident stroke events. RESULTS - Over 263 489 person-years of follow-up, 135 incident ICH events occurred. In a multivariable model, age, African-American ethnicity (versus Whites), and hypertension were positively associated with incident ICH, whereas low-density lipoprotein cholesterol and triglycerides were inversely related to incident ICH. Participants with systolic blood pressure ≥160 mm Hg or diastolic blood pressure ≥110 mm Hg had 5.55 (95% CI 3.07 to 10.0) times the rate of ICH as nonhypertensives. Sex, smoking, alcohol intake, body mass index, waist-to-hip ratio, waist circumference, and diabetes were not related to ICH. CONCLUSIONS - In this pooled cohort the risk factors for ICH were older age, African-American ethnicity, hypertension, lower LDL-C, and lower triglycerides.
KW - Cerebral hemorrhage
KW - Epidemiology
KW - Hypertension
KW - Risk factors
KW - Stroke
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U2 - 10.1161/STROKEAHA.107.487090
DO - 10.1161/STROKEAHA.107.487090
M3 - Article
C2 - 17761915
AN - SCOPUS:34848890711
SN - 0039-2499
VL - 38
SP - 2718
EP - 2725
JO - Stroke
JF - Stroke
IS - 10
ER -