TY - JOUR
T1 - Role of supplemental calcium in the recurrence of colorectal adenomas
T2 - A metaanalysis of randomized controlled trials
AU - Shaukat, Aasma
AU - Scouras, Nicole
AU - Schünemann, Holger J.
PY - 2005/2
Y1 - 2005/2
N2 - BACKGROUND: Colorectal adenomas are neoplastic growths that are important targets for chemoprevention. Dietary calcium is thought to play an important role in chemoprevention. However, the role of calcium supplementation for preventing recurrence of adenomas is controversial. We performed a systematic review and metaanalysis to study the role of calcium supplementation in preventing recurrence of adenomas. METHODS: We searched electronic bibliographic databases (Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, CINAHL, EMBASE, and MEDLINE) and contacted authors to identify potentially eligible studies. RESULTS: We identified three trials including 1,485 subjects with previously removed adenomas who were randomized to calcium versus placebo supplementation. The study endpoint was recurrence of adenomas at the end of 3-4 yr in 1,279 patients who completed the trials. We found that the recurrence of adenomas was significantly lower in subjects randomized to calcium supplementation (RR: 0.80, CI: 0.68, 0.93; p-value = 0.004). CONCLUSIONS: This systematic review and metaanalysis suggest that calcium supplementation prevents recurrent colorectal adenomas.
AB - BACKGROUND: Colorectal adenomas are neoplastic growths that are important targets for chemoprevention. Dietary calcium is thought to play an important role in chemoprevention. However, the role of calcium supplementation for preventing recurrence of adenomas is controversial. We performed a systematic review and metaanalysis to study the role of calcium supplementation in preventing recurrence of adenomas. METHODS: We searched electronic bibliographic databases (Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, CINAHL, EMBASE, and MEDLINE) and contacted authors to identify potentially eligible studies. RESULTS: We identified three trials including 1,485 subjects with previously removed adenomas who were randomized to calcium versus placebo supplementation. The study endpoint was recurrence of adenomas at the end of 3-4 yr in 1,279 patients who completed the trials. We found that the recurrence of adenomas was significantly lower in subjects randomized to calcium supplementation (RR: 0.80, CI: 0.68, 0.93; p-value = 0.004). CONCLUSIONS: This systematic review and metaanalysis suggest that calcium supplementation prevents recurrent colorectal adenomas.
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U2 - 10.1111/j.1572-0241.2005.41220.x
DO - 10.1111/j.1572-0241.2005.41220.x
M3 - Review article
C2 - 15667497
AN - SCOPUS:13944275617
SN - 0002-9270
VL - 100
SP - 390
EP - 394
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 2
ER -