Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders

Frank J. Symons; Jason J. Wolff; Laura S. Stone; Tony K.Y. Lim; James W. Bodfish

doi:10.1007/s11689-011-9080-9

Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders

Frank J. Symons, Jason J. Wolff, Laura S. Stone, Tony K.Y. Lim, James W. Bodfish

Administration (CEHD)

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i. e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p<0.01) between the SIB and control group (SIB>control). Within-group analyses showed significant differences (p<0.05) in levels of salivary α-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB+SMD>SIB). Salivary α-amylase was significantly correlated with frequency of stereotypy among the SIB group (r=0.36, p<0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.

Original language	English (US)
Pages (from-to)	144-151
Number of pages	8
Journal	Journal of neurodevelopmental disorders
Volume	3
Issue number	2
DOIs	https://doi.org/10.1007/s11689-011-9080-9
State	Published - Jun 2011

Bibliographical note

Funding Information:
The preparation of this report was supported, in part, by NICHD Grant No. 44763 and 47201 to the University of Minnesota. We are grateful to Jamie Clary for assistance with saliva collection. Our sincere thanks go to a committed group of parents and staff for their support.

Keywords

HPA axis
Hypothalamic-pituitary-adrenal axis (HPA)
Salivary
Self-injury
Stereotypy
Sympatho-adreno-medullary system (SAM)

Access

10.1007/s11689-011-9080-9

OpenUrl availability

Full text

Cite this

Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders. / Symons, Frank J.; Wolff, Jason J.; Stone, Laura S. et al.
In: Journal of neurodevelopmental disorders, Vol. 3, No. 2, 06.2011, p. 144-151.

Research output: Contribution to journal › Article › peer-review

@article{adb885a13ac7496d90222490fdadb076,

title = "Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders",

abstract = "Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i. e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p<0.01) between the SIB and control group (SIB>control). Within-group analyses showed significant differences (p<0.05) in levels of salivary α-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB+SMD>SIB). Salivary α-amylase was significantly correlated with frequency of stereotypy among the SIB group (r=0.36, p<0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.",

keywords = "HPA axis, Hypothalamic-pituitary-adrenal axis (HPA), Salivary, Self-injury, Stereotypy, Sympatho-adreno-medullary system (SAM)",

author = "Symons, {Frank J.} and Wolff, {Jason J.} and Stone, {Laura S.} and Lim, {Tony K.Y.} and Bodfish, {James W.}",

note = "Funding Information: The preparation of this report was supported, in part, by NICHD Grant No. 44763 and 47201 to the University of Minnesota. We are grateful to Jamie Clary for assistance with saliva collection. Our sincere thanks go to a committed group of parents and staff for their support.",

year = "2011",

month = jun,

doi = "10.1007/s11689-011-9080-9",

language = "English (US)",

volume = "3",

pages = "144--151",

journal = "Journal of neurodevelopmental disorders",

issn = "1866-1947",

publisher = "Springer New York",

number = "2",

}

TY - JOUR

T1 - Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders

AU - Symons, Frank J.

AU - Wolff, Jason J.

AU - Stone, Laura S.

AU - Lim, Tony K.Y.

AU - Bodfish, James W.

N1 - Funding Information: The preparation of this report was supported, in part, by NICHD Grant No. 44763 and 47201 to the University of Minnesota. We are grateful to Jamie Clary for assistance with saliva collection. Our sincere thanks go to a committed group of parents and staff for their support.

PY - 2011/6

Y1 - 2011/6

N2 - Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i. e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p<0.01) between the SIB and control group (SIB>control). Within-group analyses showed significant differences (p<0.05) in levels of salivary α-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB+SMD>SIB). Salivary α-amylase was significantly correlated with frequency of stereotypy among the SIB group (r=0.36, p<0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.

AB - Salivary levels of biomarkers for the hypothalamic-pituitary-adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i. e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p<0.01) between the SIB and control group (SIB>control). Within-group analyses showed significant differences (p<0.05) in levels of salivary α-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB+SMD>SIB). Salivary α-amylase was significantly correlated with frequency of stereotypy among the SIB group (r=0.36, p<0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.

KW - HPA axis

KW - Hypothalamic-pituitary-adrenal axis (HPA)

KW - Salivary

KW - Self-injury

KW - Stereotypy

KW - Sympatho-adreno-medullary system (SAM)

UR - http://www.scopus.com/inward/record.url?scp=79958025203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958025203&partnerID=8YFLogxK

U2 - 10.1007/s11689-011-9080-9

DO - 10.1007/s11689-011-9080-9

M3 - Article

C2 - 21484195

AN - SCOPUS:79958025203

SN - 1866-1947

VL - 3

SP - 144

EP - 151

JO - Journal of neurodevelopmental disorders

JF - Journal of neurodevelopmental disorders

IS - 2

ER -

Salivary biomarkers of HPA axis and autonomic activity in adults with intellectual disability with and without stereotyped and self-injurious behavior disorders

Abstract

Bibliographical note

Keywords

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this