Selective Csp2-Csp bond cleavage: The nitrogenation of alkynes to amides

Chong Qin; Peng Feng; Yang Ou; Tao Shen; Teng Wang; Ning Jiao

doi:10.1002/anie.201303376

Selective C_sp²-C_sp bond cleavage: The nitrogenation of alkynes to amides

Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang, Ning Jiao

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

Breakthrough: A novel catalyzed direct highly selective C sp 2-C _sp bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C sp 2-C_sp bond cleavage of aryl-substituted alkynes. The oxidant-free and mild conditions and wide substrate scope make this method very practical.

Original language	English (US)
Pages (from-to)	7850-7854
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	30
DOIs	https://doi.org/10.1002/anie.201303376
State	Published - Jul 22 2013
Externally published	Yes

Keywords

C-C bond cleavage
alkynes
amides
gold
rearrangement

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10.1002/anie.201303376

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Cite this

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abstract = "Breakthrough: A novel catalyzed direct highly selective C sp 2-C sp bond functionalization of alkynes to amides has been developed. Nitrogenation is achieved by the highly selective C sp 2-Csp bond cleavage of aryl-substituted alkynes. The oxidant-free and mild conditions and wide substrate scope make this method very practical.",

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AU - Qin, Chong

AU - Feng, Peng

AU - Ou, Yang

AU - Shen, Tao

AU - Wang, Teng

AU - Jiao, Ning

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KW - C-C bond cleavage

KW - alkynes

KW - amides

KW - gold

KW - rearrangement

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