TY - JOUR
T1 - Self-reported marijuana use over 25 years and abdominal adiposity
T2 - the Coronary Artery Risk Development in Young Adults (CARDIA) Study
AU - Bancks, Michael P.
AU - Auer, Reto
AU - Carr, J. Jeffrey
AU - Goff, David C.
AU - Kiefe, Catarina
AU - Rana, Jamal S.
AU - Reis, Jared
AU - Sidney, Stephen
AU - Terry, James G.
AU - Schreiner, Pamela J.
N1 - Publisher Copyright:
© 2017 Society for the Study of Addiction
PY - 2018/4
Y1 - 2018/4
N2 - Aims: We investigated the association between cumulative lifetime and current marijuana use with total abdominal adipose tissue (AT), visceral AT, subcutaneous AT, intermuscular AT, and mean liver attenuation (LA) at mid-life. Design: Longitudinal and cross-sectional secondary data analysis of participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Setting: CARDIA field centers in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA, USA. Participants: CARDIA participants, aged 18–30 years in 1985–1986, who were present at the clinic examination in 2010–2011 (n = 2902). Measurements: Marijuana use was assessed from responses to self-administered questionnaires at 8 CARDIA examinations over 25 years, determined as cumulative marijuana-years and current use status. Non-contrast computed tomography imaging of the abdomen was obtained in 2010–2011. Findings: In 2010–2011, 84% of participants reported a history of marijuana use with 11% reporting use within the past 30 days. Before adjustment, we observed greater cumulative marijuana use was associated with lower total abdominal and subcutaneous AT volume and lower LA and current marijuana use was associated with lower subcutaneous AT. However, after adjustment for age, sex, race, field center, cigarette pack-years and current use, regular alcohol consumption, cumulative drink-years, and physical activity, neither cumulative marijuana use nor current use showed an association with any abdominal adipose depot. Our estimates did not differ by age, sex, or race nor after accounting for cohort attrition. Conclusion: Neither cumulative marijuana use nor current marijuana use is associated with total abdominal, visceral, subcutaneous, or intermuscular adipose tissue, or liver attenuation in mid-life.
AB - Aims: We investigated the association between cumulative lifetime and current marijuana use with total abdominal adipose tissue (AT), visceral AT, subcutaneous AT, intermuscular AT, and mean liver attenuation (LA) at mid-life. Design: Longitudinal and cross-sectional secondary data analysis of participants in the Coronary Artery Risk Development in Young Adults (CARDIA) Study. Setting: CARDIA field centers in Birmingham, AL; Chicago, IL; Minneapolis, MN; and Oakland, CA, USA. Participants: CARDIA participants, aged 18–30 years in 1985–1986, who were present at the clinic examination in 2010–2011 (n = 2902). Measurements: Marijuana use was assessed from responses to self-administered questionnaires at 8 CARDIA examinations over 25 years, determined as cumulative marijuana-years and current use status. Non-contrast computed tomography imaging of the abdomen was obtained in 2010–2011. Findings: In 2010–2011, 84% of participants reported a history of marijuana use with 11% reporting use within the past 30 days. Before adjustment, we observed greater cumulative marijuana use was associated with lower total abdominal and subcutaneous AT volume and lower LA and current marijuana use was associated with lower subcutaneous AT. However, after adjustment for age, sex, race, field center, cigarette pack-years and current use, regular alcohol consumption, cumulative drink-years, and physical activity, neither cumulative marijuana use nor current use showed an association with any abdominal adipose depot. Our estimates did not differ by age, sex, or race nor after accounting for cohort attrition. Conclusion: Neither cumulative marijuana use nor current marijuana use is associated with total abdominal, visceral, subcutaneous, or intermuscular adipose tissue, or liver attenuation in mid-life.
KW - Abdominal adiposity
KW - computed tomography
KW - epidemiology
KW - marijuana use
KW - observational
KW - young adulthood
UR - http://www.scopus.com/inward/record.url?scp=85038100412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85038100412&partnerID=8YFLogxK
U2 - 10.1111/add.14097
DO - 10.1111/add.14097
M3 - Article
C2 - 29127726
AN - SCOPUS:85038100412
SN - 0965-2140
VL - 113
SP - 689
EP - 698
JO - Addiction
JF - Addiction
IS - 4
ER -