Abstract
Coupling between brevifoliol (1) and β-lactam (2) yielded, after protecting group removal, brevifoliol 13-[N-benzoyl-(2′R,3′S)-3′-phenylisoserinate] (3). This novel taxol analogue was found to be inactive in the microtubule binding assay and had little cytotoxicity against B16 melanoma cells.
Original language | English (US) |
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Pages (from-to) | 1349-1350 |
Number of pages | 2 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 3 |
Issue number | 6 |
DOIs | |
State | Published - Jun 1993 |