Sepsis and multiple sclerosis: Causative links and outcomes

Đorđe Miljković; Suzana Stanisavljević; Isaac J. Jensen; Thomas S. Griffith; Vladimir P. Badovinac

doi:10.1016/j.imlet.2021.07.008

Sepsis and multiple sclerosis: Causative links and outcomes

Đorđe Miljković, Suzana Stanisavljević, Isaac J. Jensen, Thomas S. Griffith, Vladimir P. Badovinac

Urology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.

Original language	English (US)
Pages (from-to)	40-46
Number of pages	7
Journal	Immunology Letters
Volume	238
DOIs	https://doi.org/10.1016/j.imlet.2021.07.008
State	Published - Oct 2021

Bibliographical note

Funding Information:
This work was supported by Ministry of Education, Science and Technological Development of Republic of Serbia #451-03-9/2021-14/200007 (Đ.M., S.S.), Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program #6409283 (Đ.M., V.P.B., S.S.), NIH Grants R01AI114543 (V.P.B.), R21AI147064 (V.P.B.), R35GM134880 (V.P.B.), R21AI151183 (V.P.B.), R01GM115462 (T.S.G.), R35GM140881 (T.S.G.), T32AI007511 (I.J.J.), T32AI007485 (I.J.J.) and a Veterans Health Administration Merit Review Award I01BX001324 (T.S.G.).

Publisher Copyright:
© 2021

Keywords

Gut microbiota
Multiple sclerosis
Sepsis

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abstract = "Sepsis is a life-threatening condition characterized by an acute cytokine storm followed by prolonged dysfunction of the immune system in the survivors. Post-septic lymphopenia and functional deficits of the remaining immune cells lead to increased susceptibility to secondary infections and other morbid conditions causing late death in the patients. This state of post-septic immunoparalysis may also influence disorders stemming from inappropriate or overactive immune responses, such as autoimmune and immunoinflammatory diseases, including multiple sclerosis. In addition, ongoing autoimmunity likely influences the susceptibility to and outcome of sepsis. This review article addresses the bidirectional relationship between sepsis and multiple sclerosis, with a focus on the immunologic mechanisms of the interaction and potential directions for future studies.",

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note = "Funding Information: This work was supported by Ministry of Education, Science and Technological Development of Republic of Serbia #451-03-9/2021-14/200007 ({\D}.M., S.S.), Science Fund of the Republic of Serbia, Serbian Science and Diaspora Collaboration Program #6409283 ({\D}.M., V.P.B., S.S.), NIH Grants R01AI114543 (V.P.B.), R21AI147064 (V.P.B.), R35GM134880 (V.P.B.), R21AI151183 (V.P.B.), R01GM115462 (T.S.G.), R35GM140881 (T.S.G.), T32AI007511 (I.J.J.), T32AI007485 (I.J.J.) and a Veterans Health Administration Merit Review Award I01BX001324 (T.S.G.). Publisher Copyright: {\textcopyright} 2021",

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AU - Griffith, Thomas S.

AU - Badovinac, Vladimir P.

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Sepsis and multiple sclerosis: Causative links and outcomes

Abstract

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Keywords

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