SEVERE PULMONARY HYPERSENSITIVITY ASSOCIATED WITH PASSIVE TRANSFUSION OF A NEUTROPHIL-SPECIFIC ANTIBODY

R. Yomtovian; C. Press; H. Engman; W. Kline; M. Clay; D. Hammerschmidt; J. Mccullough

doi:10.1016/S0140-6736(84)90124-7

SEVERE PULMONARY HYPERSENSITIVITY ASSOCIATED WITH PASSIVE TRANSFUSION OF A NEUTROPHIL-SPECIFIC ANTIBODY

R. Yomtovian, C. Press, H. Engman, W. Kline, M. Clay, D. Hammerschmidt, J. Mccullough

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

139 Scopus citations

Abstract

A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.

Original language	English (US)
Pages (from-to)	244-246
Number of pages	3
Journal	The Lancet
Volume	323
Issue number	8371
DOIs	https://doi.org/10.1016/S0140-6736(84)90124-7
State	Published - Feb 4 1984

Bibliographical note

Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/S0140-6736(84)90124-7

OpenUrl availability

Full text

Cite this

@article{4cd1992dec964ae4850200c803292263,

title = "SEVERE PULMONARY HYPERSENSITIVITY ASSOCIATED WITH PASSIVE TRANSFUSION OF A NEUTROPHIL-SPECIFIC ANTIBODY",

abstract = "A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.",

author = "R. Yomtovian and C. Press and H. Engman and W. Kline and M. Clay and D. Hammerschmidt and J. Mccullough",

year = "1984",

month = feb,

day = "4",

doi = "10.1016/S0140-6736(84)90124-7",

language = "English (US)",

volume = "323",

pages = "244--246",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8371",

}

TY - JOUR

T1 - SEVERE PULMONARY HYPERSENSITIVITY ASSOCIATED WITH PASSIVE TRANSFUSION OF A NEUTROPHIL-SPECIFIC ANTIBODY

AU - Yomtovian, R.

AU - Press, C.

AU - Engman, H.

AU - Kline, W.

AU - Clay, M.

AU - Hammerschmidt, D.

AU - Mccullough, J.

PY - 1984/2/4

Y1 - 1984/2/4

N2 - A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.

AB - A life-threatening pulmonary hypersensitivity reaction accompanied by profound leucopenia and transient hypocomplementaemia developed in a 73-year-old man after repair of an abdominal aortic aneurysm. A neutrophil-specific antibody, anti-NA2), was demonstrated by granulocyte immunofluorescence and microagglutination in one of the transfused donor units. In addition, activated complement component C5a was generated in vitro by incubation of the patient's serum with the aortic graft material. This severe clinical reaction may have resulted from the interaction of the transfused anti-NA2 antibody with complement activation induced by the aortic graft material.

UR - http://www.scopus.com/inward/record.url?scp=0021318907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021318907&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(84)90124-7

DO - 10.1016/S0140-6736(84)90124-7

M3 - Article

C2 - 6142994

AN - SCOPUS:0021318907

SN - 0140-6736

VL - 323

SP - 244

EP - 246

JO - The Lancet

JF - The Lancet

IS - 8371

ER -

SEVERE PULMONARY HYPERSENSITIVITY ASSOCIATED WITH PASSIVE TRANSFUSION OF A NEUTROPHIL-SPECIFIC ANTIBODY

Abstract

Bibliographical note

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this