Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease

Jacqueline A. Palmer; Carolyn S. Kaufman; Eric D. Vidoni; Robyn A. Honea; Jeffrey M. Burns; Sandra A. Billinger

doi:10.3233/JAD-220359

Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease

Jacqueline A. Palmer, Carolyn S. Kaufman, Eric D. Vidoni, Robyn A. Honea, Jeffrey M. Burns, Sandra A. Billinger

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Abstract

Sex as a biological variable appears to contribute to the multifactorial etiology of Alzheimer's disease. We tested sex-based interactions between cerebrovascular function and APOE4 genotype on resistance and resilience to brain pathology and cognitive executive dysfunction in cognitively-normal older adults. Female APOE4 carriers had higher amyloid-β deposition yet achieved similar cognitive performance to males and female noncarriers. Further, female APOE4 carriers with robust cerebrovascular responses to exercise possessed lower amyloid-β. These results suggest a unique cognitive resilience and identify cerebrovascular function as a key mechanism for resistance to age-related brain pathology in females with high genetic vulnerability to Alzheimer's disease.

Original language	English (US)
Pages (from-to)	535-542
Number of pages	8
Journal	Journal of Alzheimer's Disease
Volume	90
Issue number	2
DOIs	https://doi.org/10.3233/JAD-220359
State	Published - 2022
Externally published	Yes

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© 2022 - IOS Press. All rights reserved.

Keywords

Aging
amyloid
Apolipoproteins E
cardiovascular system
cerebrovascular circulation
cognition
female
hemodynamics
ultrasound

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Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease. / Palmer, Jacqueline A.; Kaufman, Carolyn S.; Vidoni, Eric D. et al.
In: Journal of Alzheimer's Disease, Vol. 90, No. 2, 2022, p. 535-542.

Research output: Contribution to journal › Article › peer-review

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Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease

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