Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast

Zhenpeng Qin; Warren C.W. Chan; David R Boulware; Taner Akkin; Elissa K. Butler; John C Bischof

doi:10.1002/anie.201200997

Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast

Zhenpeng Qin, Warren C.W. Chan, David R Boulware, Taner Akkin, Elissa K. Butler, John C Bischof

Research output: Contribution to journal › Article › peer-review

154 Scopus citations

Abstract

Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y).

Original language	English (US)
Pages (from-to)	4358-4361
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	18
DOIs	https://doi.org/10.1002/anie.201200997
State	Published - Apr 27 2012

Keywords

biosensors
diagnostics
immunoassays
nanoparticles
thermal contrast

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abstract = "Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y).",

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AU - Butler, Elissa K.

AU - Bischof, John C

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KW - diagnostics

KW - immunoassays

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Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast

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