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Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation
R. A. Mans, L. L. McMahon,
L. Li
Experimental and Clinical Pharmacology
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Article
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peer-review
48
Scopus citations
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Medicine & Life Sciences
farnesyl pyrophosphate
100%
Prenylation
90%
Simvastatin
76%
Long-Term Potentiation
73%
Psychological Inhibition
52%
Terpenes
22%
Cholesterol
20%
geranylgeranyl pyrophosphate
14%
Cognition
14%
Hydroxymethylglutaryl CoA Reductases
12%
Aptitude
12%
Biosynthetic Pathways
11%
Transferases
9%
Phosphatidylinositol 3-Kinase
9%
Hypercholesterolemia
9%
Amyloid
8%
Inbred C57BL Mouse
8%
Transgenic Mice
8%
Hippocampus
7%
Alzheimer Disease
7%
Learning
6%
Memory
6%
Therapeutics
4%
Brain
4%