Abstract
A genetic linkage map of the horse consisting of 742 markers, which comprises a single linkage group for each of the autosomes and the X chromosome, is presented. The map has been generated from two three-generation full-sibling reference families, sired by the same stallion, in which there are 61 individuals in the F2 generation. Each linkage group has been assigned to a chromosome and oriented with reference to markers mapped by fluorescence in situ hybridization. The average interval between markers is 3.7 cM and the linkage groups collectively span 2772 cM. The 742 markers comprise 734 microsatellite and 8 gene-based markers. The utility of the microsatellite markers for comparative mapping has been significantly enhanced by comparing their flanking sequences with the human genome sequence; this enabled conserved segments between human and horse to be identified. The new map provides a valuable resource for genetically mapping traits of interest in the horse.
Original language | English (US) |
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Pages (from-to) | 1-29 |
Number of pages | 29 |
Journal | Genomics |
Volume | 87 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2006 |
Bibliographical note
Funding Information:We thank the Horserace Betting Levy Board and the Childwick Trust for generous financial support. We also acknowledge the Dorothy Russell Havemeyer Foundation for their continuing support of collaboration in this field by financing International Workshops. We are grateful to the laboratories that contributed to this effort by providing primers for microsatellite markers, including INRA Centre de Recherches de Jouy, France; the College of Veterinary Medicine, University of Minnesota; the Equine Research Institute, Japan Racing Association, Japan; Uppsala University, Sweden; and the Norwegian College of Veterinary Medicine, Oslo, Norway.
Keywords
- Comparative map
- Genetic map
- Horse
- Linkage map
- Radiation hybrid map