Abstract
Small-angle scattering (SAS) is a versatile analytical technique that provides detailed structural information from a sample at the length scale of nanometers. In this overview, we discuss the basic principles of SAS and the diverse applications of the technique in characterization of pharmaceutical materials. Examples include identification of liquid-crystalline mesophase of drugs, influence of excipient microstructure on the final product performance, and formulation optimization of solid dispersions as well as protein-based therapeutics.
| Original language | English (US) |
|---|---|
| Article number | 116144 |
| Journal | TrAC - Trends in Analytical Chemistry |
| Volume | 134 |
| DOIs | |
| State | Published - Jan 2021 |
Bibliographical note
Publisher Copyright:© 2020 Elsevier B.V.
Keywords
- Excipients
- Liquid-crystalline mesophase
- Microstructure
- Polymorphs
- Protein formulations
- Small-angle X-ray scattering
- Small-angle neutron scattering
- Small-angle scattering
- Solid dispersion