TY - JOUR
T1 - Solubility properties of chlorhexidine salts
AU - Zeng, Pengyung
AU - Rao, Aruna
AU - Wiedmann, Timothy Scott
AU - Bowles, Walter
PY - 2009/2
Y1 - 2009/2
N2 - Chlorhexidine (CHX) is effective in treating oral bacterial infections. The solubility was shown to be highly dependent on the salt present in solution. Gluconate enhances the amount of CHX diacetate in solution possibly through mixed micelles formation, because the solubility product is such that the concentration of CHX will exceed the critical micelle concentration. However, only low concentrations of CHX dichloride can be obtained, which is not appreciably solubilized by gluconate ions. The low concentration of CHX that can be achieved in physiological concentrations of chloride in the oral cavity may be problematic for dental, slow release formulations.
AB - Chlorhexidine (CHX) is effective in treating oral bacterial infections. The solubility was shown to be highly dependent on the salt present in solution. Gluconate enhances the amount of CHX diacetate in solution possibly through mixed micelles formation, because the solubility product is such that the concentration of CHX will exceed the critical micelle concentration. However, only low concentrations of CHX dichloride can be obtained, which is not appreciably solubilized by gluconate ions. The low concentration of CHX that can be achieved in physiological concentrations of chloride in the oral cavity may be problematic for dental, slow release formulations.
KW - Chlorhexidine
KW - Chlorhexidine diacetate
KW - Chlorhexidine dichloride
KW - Chlorhexidine digluconate
KW - Micelle
KW - Solubility product
UR - http://www.scopus.com/inward/record.url?scp=60749100406&partnerID=8YFLogxK
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U2 - 10.1080/03639040802220318
DO - 10.1080/03639040802220318
M3 - Article
C2 - 18785046
AN - SCOPUS:60749100406
SN - 0363-9045
VL - 35
SP - 172
EP - 176
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
IS - 2
ER -