Spatial and Temporal Organization of the Individual Human Cerebellum

Scott Marek; Joshua S. Siegel; Evan M. Gordon; Ryan V. Raut; Caterina Gratton; Dillan J. Newbold; Mario Ortega; Timothy O. Laumann; Babatunde Adeyemo; Derek B. Miller; Annie Zheng; Katherine C. Lopez; Jeffrey J. Berg; Rebecca S. Coalson; Annie L. Nguyen; Donna Dierker; Andrew N. Van; Catherine R. Hoyt; Kathleen B. McDermott; Scott A. Norris; Joshua S. Shimony; Abraham Z. Snyder; Steven M. Nelson; Deanna M. Barch; Bradley L. Schlaggar; Marcus E. Raichle; Steven E. Petersen; Deanna J. Greene; Nico U.F. Dosenbach

doi:10.1016/j.neuron.2018.10.010

Spatial and Temporal Organization of the Individual Human Cerebellum

Scott Marek, Joshua S. Siegel, Evan M. Gordon, Ryan V. Raut, Caterina Gratton, Dillan J. Newbold, Mario Ortega, Timothy O. Laumann, Babatunde Adeyemo, Derek B. Miller, Annie Zheng, Katherine C. Lopez, Jeffrey J. Berg, Rebecca S. Coalson, Annie L. Nguyen, Donna Dierker, Andrew N. Van, Catherine R. Hoyt, Kathleen B. McDermott, Scott A. NorrisJoshua S. Shimony, Abraham Z. Snyder, Steven M. Nelson, Deanna M. Barch, Bradley L. Schlaggar, Marcus E. Raichle, Steven E. Petersen, Deanna J. Greene, Nico U.F. Dosenbach

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172 Scopus citations

Abstract

Cerebellar functional networks are topographically individual-specific. Cerebellar intrinsic fMRI signals lag those in cortex by 100–400 ms. The frontoparietal control network is greatly overrepresented (>2-fold), suggesting that the cerebellum is important for the adaptive control of the brain's cognitive processes.

Original language	English (US)
Pages (from-to)	977-993.e7
Journal	Neuron
Volume	100
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2018.10.010
State	Published - Nov 21 2018
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by NIH grants 5T32 MH100019-02 (S.M.), NS088590 (N.U.F.D.), TR000448 (N.U.F.D.), MH100872 (T.O.L.), 1R25MH112473 (T.O.L.), MH109589 (D.M.B.), MH104592 (D.J.G.), 1P30NS098577 (to the Neuroimaging Informatics and Analysis Center), and HD087011 (to the Intellectual and Developmental Disabilities Research Center at Washington University); the Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (N.U.F.D.); the McDonnell Center for Systems Neuroscience (N.U.F.D. and B.L.S.); the Mallinckrodt Institute of Radiology grant 14-011 (N.U.F.D.); the Hope Center for Neurological Disorders (N.U.F.D., B.L.S., and S.E.P.); and Dart Neuroscience LLC (K.B.M.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the U.S. government.

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

fMRI
frontoparietal network
functional networks
human cerebellum
individual variability
resting state functional connectivity
temporal lags

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Marek, S., Siegel, J. S., Gordon, E. M., Raut, R. V., Gratton, C., Newbold, D. J., Ortega, M., Laumann, T. O., Adeyemo, B., Miller, D. B., Zheng, A., Lopez, K. C., Berg, J. J., Coalson, R. S., Nguyen, A. L., Dierker, D., Van, A. N., Hoyt, C. R., McDermott, K. B., ... Dosenbach, N. U. F. (2018). Spatial and Temporal Organization of the Individual Human Cerebellum. Neuron, 100(4), 977-993.e7. https://doi.org/10.1016/j.neuron.2018.10.010

Marek, S, Siegel, JS, Gordon, EM, Raut, RV, Gratton, C, Newbold, DJ, Ortega, M, Laumann, TO, Adeyemo, B, Miller, DB, Zheng, A, Lopez, KC, Berg, JJ, Coalson, RS, Nguyen, AL, Dierker, D, Van, AN, Hoyt, CR, McDermott, KB, Norris, SA, Shimony, JS, Snyder, AZ, Nelson, SM, Barch, DM, Schlaggar, BL, Raichle, ME, Petersen, SE, Greene, DJ & Dosenbach, NUF 2018, 'Spatial and Temporal Organization of the Individual Human Cerebellum', Neuron, vol. 100, no. 4, pp. 977-993.e7. https://doi.org/10.1016/j.neuron.2018.10.010

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abstract = "Cerebellar functional networks are topographically individual-specific. Cerebellar intrinsic fMRI signals lag those in cortex by 100–400 ms. The frontoparietal control network is greatly overrepresented (>2-fold), suggesting that the cerebellum is important for the adaptive control of the brain's cognitive processes.",

keywords = "fMRI, frontoparietal network, functional networks, human cerebellum, individual variability, resting state functional connectivity, temporal lags",

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note = "Funding Information: This work was supported by NIH grants 5T32 MH100019-02 (S.M.), NS088590 (N.U.F.D.), TR000448 (N.U.F.D.), MH100872 (T.O.L.), 1R25MH112473 (T.O.L.), MH109589 (D.M.B.), MH104592 (D.J.G.), 1P30NS098577 (to the Neuroimaging Informatics and Analysis Center), and HD087011 (to the Intellectual and Developmental Disabilities Research Center at Washington University); the Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (N.U.F.D.); the McDonnell Center for Systems Neuroscience (N.U.F.D. and B.L.S.); the Mallinckrodt Institute of Radiology grant 14-011 (N.U.F.D.); the Hope Center for Neurological Disorders (N.U.F.D., B.L.S., and S.E.P.); and Dart Neuroscience LLC (K.B.M.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the U.S. government. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

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AU - Gordon, Evan M.

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AU - Gratton, Caterina

AU - Newbold, Dillan J.

AU - Ortega, Mario

AU - Laumann, Timothy O.

AU - Adeyemo, Babatunde

AU - Miller, Derek B.

AU - Zheng, Annie

AU - Lopez, Katherine C.

AU - Berg, Jeffrey J.

AU - Coalson, Rebecca S.

AU - Nguyen, Annie L.

AU - Dierker, Donna

AU - Van, Andrew N.

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AU - McDermott, Kathleen B.

AU - Norris, Scott A.

AU - Shimony, Joshua S.

AU - Snyder, Abraham Z.

AU - Nelson, Steven M.

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AU - Schlaggar, Bradley L.

AU - Raichle, Marcus E.

AU - Petersen, Steven E.

AU - Greene, Deanna J.

AU - Dosenbach, Nico U.F.

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KW - individual variability

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SP - 977-993.e7

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ER -

Spatial and Temporal Organization of the Individual Human Cerebellum

Abstract

Bibliographical note

Keywords

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