SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Pan Chen; Xiaofang Guo; Houde Zhou; Wenling Zhang; Zhaoyang Zeng; Qianjin Liao; Xiayu Li; Bo Xiang; Jianbo Yang; Jian Ma; Ming Zhou; Shuping Peng; Juanjuan Xiang; Xiaoling Li; Colvin Wanshura Le; Wei Xiong; James B. McCarthy; Guiyuan Li

doi:10.1371/journal.pone.0056929

SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

Pan Chen, Xiaofang Guo, Houde Zhou, Wenling Zhang, Zhaoyang Zeng, Qianjin Liao, Xiayu Li, Bo Xiang, Jianbo Yang, Jian Ma, Ming Zhou, Shuping Peng, Juanjuan Xiang, Xiaoling Li, Colvin Wanshura Le, Wei Xiong, James B. McCarthy, Guiyuan Li

Laboratory Medicine and Pathology

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27 Scopus citations

Abstract

Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.

Original language	English (US)
Article number	e56929
Journal	PloS one
Volume	8
Issue number	3
DOIs	https://doi.org/10.1371/journal.pone.0056929
State	Published - Mar 5 2013

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Chen, P., Guo, X., Zhou, H., Zhang, W., Zeng, Z., Liao, Q., Li, X., Xiang, B., Yang, J., Ma, J., Zhou, M., Peng, S., Xiang, J., Li, X., Le, C. W., Xiong, W., McCarthy, J. B., & Li, G. (2013). SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1. PloS one, 8(3), Article e56929. https://doi.org/10.1371/journal.pone.0056929

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abstract = "Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.",

author = "Pan Chen and Xiaofang Guo and Houde Zhou and Wenling Zhang and Zhaoyang Zeng and Qianjin Liao and Xiayu Li and Bo Xiang and Jianbo Yang and Jian Ma and Ming Zhou and Shuping Peng and Juanjuan Xiang and Xiaoling Li and Le, {Colvin Wanshura} and Wei Xiong and McCarthy, {James B.} and Guiyuan Li",

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AU - Guo, Xiaofang

AU - Zhou, Houde

AU - Zhang, Wenling

AU - Zeng, Zhaoyang

AU - Liao, Qianjin

AU - Li, Xiayu

AU - Xiang, Bo

AU - Yang, Jianbo

AU - Ma, Jian

AU - Zhou, Ming

AU - Peng, Shuping

AU - Xiang, Juanjuan

AU - Li, Xiaoling

AU - Le, Colvin Wanshura

AU - Xiong, Wei

AU - McCarthy, James B.

AU - Li, Guiyuan

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AB - Little is known about the role of the host defensive protein short palate, lung and nasal epithelium clone 1 (SPLUNC1) in the carcinogenesis of nasopharyngeal carcinoma (NPC). Here we report that SPLUNC1 plays a role at a very early stage of NPC carcinogenesis. SPLUNC1 regulates NPC cell proliferation, differentiation and apoptosis through miR-141, which in turn regulates PTEN and p27 expression. This signaling axis is negatively regulated by the EBV-coded gene LMP1. Therefore we propose that SPLUNC1 suppresses NPC tumor formation and its inhibition by LMP1 provides a route for NPC tumorigenesis.

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SPLUNC1 Regulates Cell Progression and Apoptosis through the miR-141-PTEN/p27 Pathway, but Is Hindered by LMP1

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