Abstract
In an effort to develop a tablet product of celecoxib by overcoming its poor physicochemical properties using a pharmaceutically acceptable solvate, we isolated two stoichiometric N-Methyl-2-Pyrrolidone (NMP) solvates of celecoxib (CEL), mono-NMP and di-NMP solvates. Here, we report the preparation, characterization, and structural origin of different properties of the two CEL solvates, including a rare and complex heating induced phase transformation from di-NMP to mono-NMP solvate.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 277-286 |
| Number of pages | 10 |
| Journal | Crystal Growth and Design |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 6 2021 |
Bibliographical note
Funding Information:K.W. was partially supported by the Edward G. Rippie Fellowship and the David J.W. Grant & Marilyn J. Grant Fellowship from the Department of Pharmaceutics, University of Minnesota. Parts of this work were carried out in the Characterization Facility, University of Minnesota, a member of the NSF-funded Materials Research Facilities Network ( www.mrfn.org ) via the MRSEC program. We thank the Minnesota Supercomputing Institute (MSI) at the University of Minnesota for providing the resources that contributed to the research results reported within this paper ( http://www.msi.umn.edu ). The Bruker-AXS D8 Venture diffractometer was purchased through a grant from NSF/MRI (#1229400) and the University of Minnesota.
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