Structure-activity analysis of the Pseudomonas quinolone signal molecule

James Hodgkinson; Steven D. Bowden; Warren R J D Galloway; David R. Spring; Martin Welch

doi:10.1128/JB.00081-10

Structure-activity analysis of the Pseudomonas quinolone signal molecule

James Hodgkinson, Steven D. Bowden, Warren R J D Galloway, David R. Spring, Martin Welch

Food Science and Nutrition

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47 Scopus citations

Abstract

We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production.

Original language	English (US)
Pages (from-to)	3833-3837
Number of pages	5
Journal	Journal of bacteriology
Volume	192
Issue number	14
DOIs	https://doi.org/10.1128/JB.00081-10
State	Published - Jul 2010

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Structure-activity analysis of the Pseudomonas quinolone signal molecule

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