Abstract
Transcription activation is an important checkpoint of regulation of gene expression which occurs in response to different intracellular and extracellular signals. The key elements in this signal transduction process are transcription activators, which determine when and how gene expression is activated. Recent structural studies on a considerable number of new transcription activation complexes (TACs) revealed the remarkable mechanistic diversity of transcription activation mediated by different factors, necessitating a review and re-evaluation of the transcription activation mechanisms. In this review, we present a comprehensive summary of transcription activation mechanisms and propose a new, elaborate, and systematic classification of transcription activation mechanisms, primarily based on the structural features of diverse TAC components.
Original language | English (US) |
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Pages (from-to) | 379-397 |
Number of pages | 19 |
Journal | Trends in Microbiology |
Volume | 32 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2024 |
Bibliographical note
Publisher Copyright:© 2023 Elsevier Ltd
Keywords
- DNA promoter
- RNA polymerase
- gene regulation
- sigma factor
- transcription activation
- transcription factor
PubMed: MeSH publication types
- Journal Article
- Review