TY - JOUR
T1 - Structure of de-oxy corticosterone-21-hemisuccinate
AU - Dey, Raja
AU - Roychowdhury, Sandhya
AU - Roychowdhury, P.
PY - 1999/12
Y1 - 1999/12
N2 - Synthetic glucocorticoid de-oxy corticosterone-21-hemisuccinate crystallizes in the monoclinic space group C2, with a = 21.896(2), b = 7.596(3) and c = 14.291(3) Å, Z = 4. Ring A is a distorted half chair, ring B and C are in the chair configuration and ring D is in the 14α-half chair configuration. The ring junctions B/C and C/D are both trans. The molecule as a whole is slightly convex towards the β-side, with an angle of 18.4(2)° between the C(10) - C(19) and C(13) - C(18) vectors. In addition to packing and stacking interaction, intermolecular hydrogen bonding plays an important role in structural association. The X-ray structure determination of the title compound was undertaken to study its high binding affinity to serum protein like globulin.
AB - Synthetic glucocorticoid de-oxy corticosterone-21-hemisuccinate crystallizes in the monoclinic space group C2, with a = 21.896(2), b = 7.596(3) and c = 14.291(3) Å, Z = 4. Ring A is a distorted half chair, ring B and C are in the chair configuration and ring D is in the 14α-half chair configuration. The ring junctions B/C and C/D are both trans. The molecule as a whole is slightly convex towards the β-side, with an angle of 18.4(2)° between the C(10) - C(19) and C(13) - C(18) vectors. In addition to packing and stacking interaction, intermolecular hydrogen bonding plays an important role in structural association. The X-ray structure determination of the title compound was undertaken to study its high binding affinity to serum protein like globulin.
KW - Corticosteroid
KW - Crystal structure
KW - De-oxy corticosterone-21-hemisuccinate
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U2 - 10.1023/A:1009504923424
DO - 10.1023/A:1009504923424
M3 - Article
AN - SCOPUS:0033473217
SN - 1074-1542
VL - 29
SP - 1265
EP - 1269
JO - Journal of Chemical Crystallography
JF - Journal of Chemical Crystallography
IS - 12
ER -