Abstract
A fluorinated lipid, 1-palmitoyl-2-8,8-difiuoropalmitoyl-sn-glycero-3-phosphorylcholine, has been synthesized and the dynamic properties of lipid bilayer systems containing this molecule have been studied using fluorine-19 NMR. Spin-lattice relaxation rates and nuclear Overhauser effects have been measured over a range of temperatures and the results have been interpreted in terms of correlation times for specific motions involving the gem-difluoromethylene group. The correlation times are shown to be consistent with and 13C relaxation data of similar lipid bilayer systems. The data, however, prove to be particularly valuable in characterizing a motion on the time scale of translational diffusion.
Original language | English (US) |
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Pages (from-to) | 3749-3755 |
Number of pages | 7 |
Journal | Journal of the American Chemical Society |
Volume | 98 |
Issue number | 13 |
DOIs | |
State | Published - Jun 1 1976 |