TY - JOUR
T1 - Synthesis and activity of new acylated diaminohydroxyalkanes as human immunodeficiency virus protease inhibitors
AU - Marastoni, Mauro
AU - Bazzaro, Martina
AU - Bortolotti, Fabrizio
AU - Tomatis, Roberto
PY - 2000
Y1 - 2000
N2 - A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.
AB - A series of HIV-1 protease inhibitors based on the lead compound Pc (IC50 = 165 nmol/l) with structural modifications at P1/P1' substituents or with a lengthening at its core unit were synthesized from amino acid starting materials. All analogues were less active than Pc against the protease.
KW - HIV-1 protease inhibitors
KW - Peptidomimetics
UR - http://www.scopus.com/inward/record.url?scp=0033946219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033946219&partnerID=8YFLogxK
U2 - 10.1055/s-0031-1300250
DO - 10.1055/s-0031-1300250
M3 - Article
C2 - 10918952
AN - SCOPUS:0033946219
SN - 0004-4172
VL - 50
SP - 564
EP - 568
JO - Arzneimittel-Forschung/Drug Research
JF - Arzneimittel-Forschung/Drug Research
IS - 6
ER -
