TY - JOUR
T1 - Synthesis and biology of substituted 3′-phenyl taxol analogues
AU - Georg, Gunda I.
AU - Cheruvallath, Zacharia S.
AU - Harriman, Geraldin C.B.
AU - Hepperle, Michael
AU - Park, Haeil
AU - Himes, Richard H.
PY - 1994/10/6
Y1 - 1994/10/6
N2 - A series of substituted 3′-phenyl taxol analogues, directed by the Topliss Operational Scheme, were synthesized and evaluated for their biological activity. The novel analogues were prepared from baccatin III and N-acyl β-lactams. Evaluation in the microtubule assembly assay and for cytotoxicity against B16 melanoma cells illustrated a modest influence of aromatic substitution on bioactivity.
AB - A series of substituted 3′-phenyl taxol analogues, directed by the Topliss Operational Scheme, were synthesized and evaluated for their biological activity. The novel analogues were prepared from baccatin III and N-acyl β-lactams. Evaluation in the microtubule assembly assay and for cytotoxicity against B16 melanoma cells illustrated a modest influence of aromatic substitution on bioactivity.
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U2 - 10.1016/0960-894X(94)85035-6
DO - 10.1016/0960-894X(94)85035-6
M3 - Article
AN - SCOPUS:0027998451
SN - 0960-894X
VL - 4
SP - 2331
EP - 2336
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 19
ER -
