Abstract
An efficient, two steps synthesis of p-coumaric acid amides was described. The key intermediate, 3-(4-hydroxyphenyl) acryloyl chloride (2) was obtained by conversion of p-coumaric acid (1) to its acid chloride in presence of thionyl chloride. Further, coupling of different aminophenols and substituted aminophenols by base condensation reaction affords p-coumaric acid amides (2a-e). The newly synthesized compounds were characterized by spectral and elemental analysis data and studied for their antioxidant properties using 2,2-diphenyl-l-picryl hydrazyl (DPPH) radical scavenging assay and inhibition on human Low-density lipoprotein (LDL) assay. All the compounds exhibited good potent activity dose dependently. Butylated hydroxy anisole (BHA) was used as a reference antioxidant and also the comparative study with newly synthesized compounds was done.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 57-62 |
| Number of pages | 6 |
| Journal | International Journal of Pharmacy and Pharmaceutical Sciences |
| Volume | 3 |
| Issue number | 4 |
| State | Published - 2011 |
Keywords
- 3-(4-Hydroxyphenyl) acryloyl chloride
- Aminophenols
- DPPH
- p-Coumaric acid