Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial, a randomized controlled trial

Maria L. Geisinger; Bryan S. Michalowicz; Wei Hou; Elinor Schoenfeld; Marie Gelato; Steven P. Engebretson; Michael S. Reddy; Leslie Hyman

doi:10.1902/jop.2016.150727

Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial, a randomized controlled trial

Maria L. Geisinger, Bryan S. Michalowicz, Wei Hou, Elinor Schoenfeld, Marie Gelato, Steven P. Engebretson, Michael S. Reddy, Leslie Hyman

Periodontology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Background: The present study evaluates effects of non-surgical periodontal treatment on serum biomarkers in patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis who participated in the Diabetes and Periodontal Therapy Trial (DPTT); and associations among diabetes markers, serum biomarkers, and periodontal measures in these patients. Methods: DPTT participants randomized to receive immediate or delayed non-surgical periodontal therapy were evaluated at baseline and 6 months. Serum samples from 475 participants with 6-month data were analyzed for the following biomarkers: 1) high sensitivity C-reactive protein; 2) E-selectin; 3) tumor necrosis factor (TNF)-α 4) vascular cell adhesion molecule (VCAM); 5) interleukin (IL)-6; 6) IL-8; 7) intercellular adhesion molecule; and 8) IL-10. Changes in biomarker levels from baseline and correlations among biomarker levels and clinical findings were analyzed. Results: No differences between treatment and control groups were observed for any biomarkers at baseline or 6 months (P >0.05 for all variables). VCAM levels increased by an average (standard deviation) of 17.9 (99.5); ng/mL (P = 0.006) and E-selectin decreased by 2.33 (16.08) ng/mL (P = 0.03) in the treatment group after 6 months. E-selectin levels were significantly correlated with DM-related variables (hemoglobin A1c [HbA1c] and fasting glucose) at baseline and with 6-month change in both groups; no significant correlations were found among periodontal clinical parameters and serum biomarkers or DM-related variables. Neither HbA1c or body mass index varied during the study period in either study group. Conclusions: Non-surgical periodontal therapy and periodontal disease severity were not associated with significant changes in serum biomarkers in DPTT participants during the 6-month follow-up. Correlations among changes in E-selectin, IL-6, and DM-related variables suggest that T2DM may be the primary driver of systemic inflammation in these patients.

Original language	English (US)
Pages (from-to)	900-913
Number of pages	14
Journal	Journal of periodontology
Volume	87
Issue number	8
DOIs	https://doi.org/10.1902/jop.2016.150727
State	Published - Aug 2016

Bibliographical note

Funding Information:
The authors would like to thank the DPTT research group (see supplementary Appendix 1 in online Journal of Periodontology) for their help in coordination, execution, and analysis of data. Specifically, the authors acknowledge Dr. Michael Tsai and Ms. Naomi Hanson of the University of Minnesota Core Laboratory, who performed biomarker analysis of the samples collected. The authors would also like to acknowledge the contributions of Drs. J Gunsolley (Chair), V. Fonesca, D. Heitjan, and J. Meigs who served on the Data andSafety Monitoring Board, andDrs. J.Atkinson (NIDCR Project Officer) and H. Hamilton (NIDCR Medical Monitor) to the DPTT study. The DPTT study was supported by cooperative agreements grants UO1 DE018902 (SE) and U01 DE018886 (LH) from the National Institute of Dental and Craniofacial Research, National Institutes of Health. Trial Registration ClinicalTrials.gov Identifier: NCT00997178. The authors report no conflicts of interest related to this study.

Keywords

Biomarkers
Cytokines
Diabetes mellitus
Periodontal diseases
Periodontitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Geisinger, M. L., Michalowicz, B. S., Hou, W., Schoenfeld, E., Gelato, M., Engebretson, S. P., Reddy, M. S., & Hyman, L. (2016). Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial, a randomized controlled trial. Journal of periodontology, 87(8), 900-913. https://doi.org/10.1902/jop.2016.150727

Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial, a randomized controlled trial. / Geisinger, Maria L.; Michalowicz, Bryan S.; Hou, Wei et al.
In: Journal of periodontology, Vol. 87, No. 8, 08.2016, p. 900-913.

Research output: Contribution to journal › Article › peer-review

Geisinger, ML, Michalowicz, BS, Hou, W, Schoenfeld, E, Gelato, M, Engebretson, SP, Reddy, MS & Hyman, L 2016, 'Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial, a randomized controlled trial', Journal of periodontology, vol. 87, no. 8, pp. 900-913. https://doi.org/10.1902/jop.2016.150727

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abstract = "Background: The present study evaluates effects of non-surgical periodontal treatment on serum biomarkers in patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis who participated in the Diabetes and Periodontal Therapy Trial (DPTT); and associations among diabetes markers, serum biomarkers, and periodontal measures in these patients. Methods: DPTT participants randomized to receive immediate or delayed non-surgical periodontal therapy were evaluated at baseline and 6 months. Serum samples from 475 participants with 6-month data were analyzed for the following biomarkers: 1) high sensitivity C-reactive protein; 2) E-selectin; 3) tumor necrosis factor (TNF)-α 4) vascular cell adhesion molecule (VCAM); 5) interleukin (IL)-6; 6) IL-8; 7) intercellular adhesion molecule; and 8) IL-10. Changes in biomarker levels from baseline and correlations among biomarker levels and clinical findings were analyzed. Results: No differences between treatment and control groups were observed for any biomarkers at baseline or 6 months (P >0.05 for all variables). VCAM levels increased by an average (standard deviation) of 17.9 (99.5); ng/mL (P = 0.006) and E-selectin decreased by 2.33 (16.08) ng/mL (P = 0.03) in the treatment group after 6 months. E-selectin levels were significantly correlated with DM-related variables (hemoglobin A1c [HbA1c] and fasting glucose) at baseline and with 6-month change in both groups; no significant correlations were found among periodontal clinical parameters and serum biomarkers or DM-related variables. Neither HbA1c or body mass index varied during the study period in either study group. Conclusions: Non-surgical periodontal therapy and periodontal disease severity were not associated with significant changes in serum biomarkers in DPTT participants during the 6-month follow-up. Correlations among changes in E-selectin, IL-6, and DM-related variables suggest that T2DM may be the primary driver of systemic inflammation in these patients.",

keywords = "Biomarkers, Cytokines, Diabetes mellitus, Periodontal diseases, Periodontitis",

author = "Geisinger, {Maria L.} and Michalowicz, {Bryan S.} and Wei Hou and Elinor Schoenfeld and Marie Gelato and Engebretson, {Steven P.} and Reddy, {Michael S.} and Leslie Hyman",

note = "Funding Information: The authors would like to thank the DPTT research group (see supplementary Appendix 1 in online Journal of Periodontology) for their help in coordination, execution, and analysis of data. Specifically, the authors acknowledge Dr. Michael Tsai and Ms. Naomi Hanson of the University of Minnesota Core Laboratory, who performed biomarker analysis of the samples collected. The authors would also like to acknowledge the contributions of Drs. J Gunsolley (Chair), V. Fonesca, D. Heitjan, and J. Meigs who served on the Data andSafety Monitoring Board, andDrs. J.Atkinson (NIDCR Project Officer) and H. Hamilton (NIDCR Medical Monitor) to the DPTT study. The DPTT study was supported by cooperative agreements grants UO1 DE018902 (SE) and U01 DE018886 (LH) from the National Institute of Dental and Craniofacial Research, National Institutes of Health. Trial Registration ClinicalTrials.gov Identifier: NCT00997178. The authors report no conflicts of interest related to this study.",

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T1 - Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial, a randomized controlled trial

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AU - Michalowicz, Bryan S.

AU - Hou, Wei

AU - Schoenfeld, Elinor

AU - Gelato, Marie

AU - Engebretson, Steven P.

AU - Reddy, Michael S.

AU - Hyman, Leslie

N1 - Funding Information: The authors would like to thank the DPTT research group (see supplementary Appendix 1 in online Journal of Periodontology) for their help in coordination, execution, and analysis of data. Specifically, the authors acknowledge Dr. Michael Tsai and Ms. Naomi Hanson of the University of Minnesota Core Laboratory, who performed biomarker analysis of the samples collected. The authors would also like to acknowledge the contributions of Drs. J Gunsolley (Chair), V. Fonesca, D. Heitjan, and J. Meigs who served on the Data andSafety Monitoring Board, andDrs. J.Atkinson (NIDCR Project Officer) and H. Hamilton (NIDCR Medical Monitor) to the DPTT study. The DPTT study was supported by cooperative agreements grants UO1 DE018902 (SE) and U01 DE018886 (LH) from the National Institute of Dental and Craniofacial Research, National Institutes of Health. Trial Registration ClinicalTrials.gov Identifier: NCT00997178. The authors report no conflicts of interest related to this study.

PY - 2016/8

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N2 - Background: The present study evaluates effects of non-surgical periodontal treatment on serum biomarkers in patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis who participated in the Diabetes and Periodontal Therapy Trial (DPTT); and associations among diabetes markers, serum biomarkers, and periodontal measures in these patients. Methods: DPTT participants randomized to receive immediate or delayed non-surgical periodontal therapy were evaluated at baseline and 6 months. Serum samples from 475 participants with 6-month data were analyzed for the following biomarkers: 1) high sensitivity C-reactive protein; 2) E-selectin; 3) tumor necrosis factor (TNF)-α 4) vascular cell adhesion molecule (VCAM); 5) interleukin (IL)-6; 6) IL-8; 7) intercellular adhesion molecule; and 8) IL-10. Changes in biomarker levels from baseline and correlations among biomarker levels and clinical findings were analyzed. Results: No differences between treatment and control groups were observed for any biomarkers at baseline or 6 months (P >0.05 for all variables). VCAM levels increased by an average (standard deviation) of 17.9 (99.5); ng/mL (P = 0.006) and E-selectin decreased by 2.33 (16.08) ng/mL (P = 0.03) in the treatment group after 6 months. E-selectin levels were significantly correlated with DM-related variables (hemoglobin A1c [HbA1c] and fasting glucose) at baseline and with 6-month change in both groups; no significant correlations were found among periodontal clinical parameters and serum biomarkers or DM-related variables. Neither HbA1c or body mass index varied during the study period in either study group. Conclusions: Non-surgical periodontal therapy and periodontal disease severity were not associated with significant changes in serum biomarkers in DPTT participants during the 6-month follow-up. Correlations among changes in E-selectin, IL-6, and DM-related variables suggest that T2DM may be the primary driver of systemic inflammation in these patients.

AB - Background: The present study evaluates effects of non-surgical periodontal treatment on serum biomarkers in patients with type 2 diabetes mellitus (T2DM) and chronic periodontitis who participated in the Diabetes and Periodontal Therapy Trial (DPTT); and associations among diabetes markers, serum biomarkers, and periodontal measures in these patients. Methods: DPTT participants randomized to receive immediate or delayed non-surgical periodontal therapy were evaluated at baseline and 6 months. Serum samples from 475 participants with 6-month data were analyzed for the following biomarkers: 1) high sensitivity C-reactive protein; 2) E-selectin; 3) tumor necrosis factor (TNF)-α 4) vascular cell adhesion molecule (VCAM); 5) interleukin (IL)-6; 6) IL-8; 7) intercellular adhesion molecule; and 8) IL-10. Changes in biomarker levels from baseline and correlations among biomarker levels and clinical findings were analyzed. Results: No differences between treatment and control groups were observed for any biomarkers at baseline or 6 months (P >0.05 for all variables). VCAM levels increased by an average (standard deviation) of 17.9 (99.5); ng/mL (P = 0.006) and E-selectin decreased by 2.33 (16.08) ng/mL (P = 0.03) in the treatment group after 6 months. E-selectin levels were significantly correlated with DM-related variables (hemoglobin A1c [HbA1c] and fasting glucose) at baseline and with 6-month change in both groups; no significant correlations were found among periodontal clinical parameters and serum biomarkers or DM-related variables. Neither HbA1c or body mass index varied during the study period in either study group. Conclusions: Non-surgical periodontal therapy and periodontal disease severity were not associated with significant changes in serum biomarkers in DPTT participants during the 6-month follow-up. Correlations among changes in E-selectin, IL-6, and DM-related variables suggest that T2DM may be the primary driver of systemic inflammation in these patients.

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KW - Cytokines

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KW - Periodontal diseases

KW - Periodontitis

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Systemic inflammatory biomarkers and their association with periodontal and diabetes-related factors in the diabetes and periodontal therapy trial, a randomized controlled trial

Abstract

Bibliographical note

Keywords

UN SDGs

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