TY - JOUR
T1 - Resident memory CD8 t cells trigger protective innate and adaptive immune responses
AU - Schenkel, Jason M
AU - Fraser, Kathryn A
AU - Beura, Lalit K
AU - Pauken, Kristen E.
AU - Vezys, Vaiva
AU - Masopust, David
N1 - Publisher Copyright:
Copyright © 2014 by the American Association for the Advancement of Science; all rights reserved.
PY - 2014/10/3
Y1 - 2014/10/3
N2 - The pathogen recognition theory dictates that, upon viral infection, the innate immune system first detects microbial products and then responds by providing instructions to adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (TRM cells), non-recirculating cells located at common sites of infection, can achieve near-sterilizing immunity against viral infections by reversing this flow of information. Upon antigen resensitization within the mouse female reproductive mucosae, CD8+ TRM cells secrete cytokines that trigger rapid adaptive and innate immune responses, including local humoral responses, maturation of local dendritic cells, and activation of natural killer cells. This provided near-sterilizing immunity against an antigenically unrelated viral infection. Thus, CD8+ TRM cells rapidly trigger an antiviral state by amplifying receptor-derived signals from previously encountered pathogens.
AB - The pathogen recognition theory dictates that, upon viral infection, the innate immune system first detects microbial products and then responds by providing instructions to adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (TRM cells), non-recirculating cells located at common sites of infection, can achieve near-sterilizing immunity against viral infections by reversing this flow of information. Upon antigen resensitization within the mouse female reproductive mucosae, CD8+ TRM cells secrete cytokines that trigger rapid adaptive and innate immune responses, including local humoral responses, maturation of local dendritic cells, and activation of natural killer cells. This provided near-sterilizing immunity against an antigenically unrelated viral infection. Thus, CD8+ TRM cells rapidly trigger an antiviral state by amplifying receptor-derived signals from previously encountered pathogens.
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U2 - 10.1126/science.1254536
DO - 10.1126/science.1254536
M3 - Article
C2 - 25170049
AN - SCOPUS:84907542588
SN - 0036-8075
VL - 346
SP - 98
EP - 101
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
IS - 6205
ER -