Tandem reduction-reductive alkylation of azido sugars

Liqiang Chen; David F. Wiemer

doi:10.1016/S0040-4039(02)00386-6

Tandem reduction-reductive alkylation of azido sugars

Liqiang Chen, David F. Wiemer

Research output: Contribution to journal › Article › peer-review

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Abstract

Catalytic hydrogenation of azido sugars has been conducted in the presence of different aldehydes to bring about a tandem reduction-reductive alkylation sequence. The reaction sequence proceeds in generally high yields, and tolerates some benzyl and benzylidene protecting groups that are sensitive to hydrogenolysis.

Original language	English (US)
Pages (from-to)	2705-2708
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	15
DOIs	https://doi.org/10.1016/S0040-4039(02)00386-6
State	Published - Apr 8 2002
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by a pilot grant funded by NIH/NIDDK P30 DK 54759 and the Cystic Fibrosis Foundation.

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abstract = "Catalytic hydrogenation of azido sugars has been conducted in the presence of different aldehydes to bring about a tandem reduction-reductive alkylation sequence. The reaction sequence proceeds in generally high yields, and tolerates some benzyl and benzylidene protecting groups that are sensitive to hydrogenolysis.",

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AU - Wiemer, David F.

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AB - Catalytic hydrogenation of azido sugars has been conducted in the presence of different aldehydes to bring about a tandem reduction-reductive alkylation sequence. The reaction sequence proceeds in generally high yields, and tolerates some benzyl and benzylidene protecting groups that are sensitive to hydrogenolysis.

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Tandem reduction-reductive alkylation of azido sugars

Abstract

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