TY - JOUR
T1 - Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual Plasmodium falciparum
AU - Chery-Karschney, Laura
AU - Patrapuvich, Rapatbhorn
AU - Mudeppa, Devaraja Gouda
AU - Kokkonda, Sreekanth
AU - Chakrabarti, Rimi
AU - Sriwichai, Patchara
AU - O'Connor, Roberta M.
AU - Rathod, Pradipsinh K.
AU - White, John
N1 - Publisher Copyright:
© 2024 American Society for Microbiology. All rights reserved.
PY - 2024/2
Y1 - 2024/2
N2 - Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.
AB - Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimalarial because it inhibits the growth of sexual and asexual blood stages of Plasmodium falciparum at sub-nanomolar levels. The potency of TrtE warrants further investigation into its mechanism of action, cytotoxicity, and ease with which parasites may evolve resistance to it.
KW - gametocidal
KW - malaria
KW - marine natural product
KW - shipworm symbiont
UR - http://www.scopus.com/inward/record.url?scp=85184521084&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85184521084&partnerID=8YFLogxK
U2 - 10.1128/aac.00684-23
DO - 10.1128/aac.00684-23
M3 - Article
C2 - 38193705
AN - SCOPUS:85184521084
SN - 0066-4804
VL - 68
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 2
ER -
