TY - JOUR
T1 - The 14-alkyl- and 14-alkenyl-5β-methylindolomorphinan series provide δ-selective partial opioid agonists
AU - Grundt, Peter
AU - Martinez-Bermejo, Fernando
AU - Lewis, John W.
AU - Husbands, Stephen M.
PY - 2003
Y1 - 2003
N2 - A series of 14β-alkyl- and 14β-alkenyl-5β-methylindolomorphinans was synthesized and evaluated in opioid binding and functional assays. While being relatively nonselective in binding assays, the 14-cinnamyl and 14-isopentyl members showed selective opioid δ-receptor partial agonist activity in [35S]GTPγS assays.
AB - A series of 14β-alkyl- and 14β-alkenyl-5β-methylindolomorphinans was synthesized and evaluated in opioid binding and functional assays. While being relatively nonselective in binding assays, the 14-cinnamyl and 14-isopentyl members showed selective opioid δ-receptor partial agonist activity in [35S]GTPγS assays.
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U2 - 10.1002/hlca.200390080
DO - 10.1002/hlca.200390080
M3 - Article
AN - SCOPUS:0242584833
SN - 0018-019X
VL - 86
SP - 793
EP - 798
JO - Helvetica Chimica Acta
JF - Helvetica Chimica Acta
IS - 3
ER -
