The bihormonal bionic pancreas improves glycemic control in individuals with hyperinsulinism and postpancreatectomy diabetes: A pilot study

Arpana Rayannavar; Lauren M. Mitteer; Courtney A. Balliro; Firas H. El-Khatib; Katherine L. Lord; Colin P. Hawkes; Lance S. Ballester; Edward R. Damiano; Steven J. Russell; Diva D. De Leon

doi:10.2337/dc21-0416

The bihormonal bionic pancreas improves glycemic control in individuals with hyperinsulinism and postpancreatectomy diabetes: A pilot study

Arpana Rayannavar, Lauren M. Mitteer, Courtney A. Balliro, Firas H. El-Khatib, Katherine L. Lord, Colin P. Hawkes, Lance S. Ballester, Edward R. Damiano, Steven J. Russell, Diva D. De Leon

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Abstract

OBJECTIVE To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC). RESEARCH DESIGN AND METHODS Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.3 mmol/L. RESULTS Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol/L in the BHBP period versus 9 (1.8) mmol/L in the UC period (P 5 0.13). Mean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period (P 5 0.11). CONCLUSIONS Relative to UC, the BHBP resulted in comparable glycemic control in our population.

Original language	English (US)
Pages (from-to)	2582-2585
Number of pages	4
Journal	Diabetes care
Volume	44
Issue number	11
DOIs	https://doi.org/10.2337/dc21-0416
State	Published - Nov 1 2021
Externally published	Yes

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Publisher Copyright:
© 2021 by the American Diabetes Association.

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Rayannavar, A., Mitteer, L. M., Balliro, C. A., El-Khatib, F. H., Lord, K. L., Hawkes, C. P., Ballester, L. S., Damiano, E. R., Russell, S. J., & De Leon, D. D. (2021). The bihormonal bionic pancreas improves glycemic control in individuals with hyperinsulinism and postpancreatectomy diabetes: A pilot study. Diabetes care, 44(11), 2582-2585. https://doi.org/10.2337/dc21-0416

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abstract = "OBJECTIVE To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC). RESEARCH DESIGN AND METHODS Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.3 mmol/L. RESULTS Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol/L in the BHBP period versus 9 (1.8) mmol/L in the UC period (P 5 0.13). Mean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period (P 5 0.11). CONCLUSIONS Relative to UC, the BHBP resulted in comparable glycemic control in our population.",

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AU - El-Khatib, Firas H.

AU - Lord, Katherine L.

AU - Hawkes, Colin P.

AU - Ballester, Lance S.

AU - Damiano, Edward R.

AU - Russell, Steven J.

AU - De Leon, Diva D.

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N2 - OBJECTIVE To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC). RESEARCH DESIGN AND METHODS Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.3 mmol/L. RESULTS Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol/L in the BHBP period versus 9 (1.8) mmol/L in the UC period (P 5 0.13). Mean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period (P 5 0.11). CONCLUSIONS Relative to UC, the BHBP resulted in comparable glycemic control in our population.

AB - OBJECTIVE To determine whether the bihormonal bionic pancreas (BHBP) improves glycemic control and reduces hypoglycemia in individuals with congenital hyperinsulinism (HI) and postpancreatectomy diabetes (PPD) compared with usual care (UC). RESEARCH DESIGN AND METHODS Ten subjects with HI and PPD completed this open-label, crossover pilot study. Coprimary outcomes were mean glucose concentration and time with continuous glucose monitoring (CGM) glucose concentration <3.3 mmol/L. RESULTS Mean (SD) CGM glucose concentration was 8.3 (0.7) mmol/L in the BHBP period versus 9 (1.8) mmol/L in the UC period (P 5 0.13). Mean (SD) time with CGM glucose concentration <3.3 mmol/L was 0% (0.002) in the BHBP period vs. 1.3% (0.018) in the UC period (P 5 0.11). CONCLUSIONS Relative to UC, the BHBP resulted in comparable glycemic control in our population.

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The bihormonal bionic pancreas improves glycemic control in individuals with hyperinsulinism and postpancreatectomy diabetes: A pilot study

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