The clinical features of the overlap between COPD and asthma

Megan Hardin; Edwin K. Silverman; R. Graham Barr; Nadia N. Hansel; Joyce D. Schroeder; Barry J. Make; James D. Crapo; Craig P. Hersh; Jeffrey Curtis; Ella Kazerooni; Nicola Hanania; Philip Alapat; Venkata Bandi; Kalpalatha Guntupalli; Elizabeth Guy; Antara Mallampalli; Charles Trinh; Mustafa Atik; Dawn DeMeo; Craig Hersh; George Washko; Francine Jacobson; R. Graham Barr; Byron Thomashow; John Austin; MacIntyre Neil MacIntyre; Lacey Washington; H. Page McAdams; Richard Rosiello; Timothy Bresnahan; Charlene McEvoy; Joseph Tashjian; Robert Wise; Nadia Hansel; Robert Brown; Gregory Diette; Richard Casaburi; Janos Porszasz; Hans Fischer; Matt Budoff; Amir Sharafkhaneh; Charles Trinh; Hirani Kamal; Roham Darvishi; Dennis Niewoehner; Tadashi Allen; Quentin Anderson; Kathryn Rice; Marilyn Foreman; Gloria Westney; Eugene Berkowitz; Russell Bowler; Adam Friedlander; David Lynch; Joyce Schroeder; John Newell; Gerard Criner; Victor Kim; Nathaniel Marchetti; Aditi Satti; A. James Mamary; Robert Steiner; Chandra Dass; William Bailey; Mark Dransfield; Hrudaya Nath; Joe Ramsdell; Paul Friedman; Geoffrey McLennan; Edwin J R van Beek; Brad Thompson; Dwight Look; Fernando Martinez; Mei Lan Han; Ella Kazerooni; Christine Wendt; Frank Sciurba; Joel Weissfeld; Carl Fuhrman; Jessica Bon; Antonio Anzueto; Sandra Adams; Carlos Orozco; Mario Ruiz; Robert Jensen; Homayoon Farzadegan; Stacey Meyerer; Shivam Chandan; Samantha Bragan; James Murphy; Douglas Everett; Ruthie Knowles; Amber Powell; John Hokanson; Black-Shinn Jennifer Black-Shinn; Gregory Kinney; James Crapo; Edwin Silverman; Barry Make; Elizabeth Regan; Jonathan Samet; Sarah Moyle; Terri Beaty; Barbara Klanderman; Nan Laird; Christophe Lange; Michael Cho; Stephanie Santorico; John Hokanson; Dawn DeMeo; Nadia Hansel; Jacqueline Hetmanski; David Lynch; Joyce Schroeder; John Newell; John Reilly; Harvey Coxson; Philip Judy; Eric Hoffman; Raul San Jose Estepar; James Ross; Rebecca Leek; Jordan Zach; Alex Kluiber; Jered Sieren; Heather Baumhauer; Verity McArthur; Dzimitry Kazlouski; Andrew Allen

doi:10.1186/1465-9921-12-127

The clinical features of the overlap between COPD and asthma

Megan Hardin, Edwin K. Silverman, R. Graham Barr, Nadia N. Hansel, Joyce D. Schroeder, Barry J. Make, James D. Crapo, Craig P. Hersh, Jeffrey Curtis, Ella Kazerooni, Nicola Hanania, Philip Alapat, Venkata Bandi, Kalpalatha Guntupalli, Elizabeth Guy, Antara Mallampalli, Charles Trinh, Mustafa Atik, Dawn DeMeo, Craig HershGeorge Washko, Francine Jacobson, R. Graham Barr, Byron Thomashow, John Austin, MacIntyre Neil MacIntyre, Lacey Washington, H. Page McAdams, Richard Rosiello, Timothy Bresnahan, Charlene McEvoy, Joseph Tashjian, Robert Wise, Nadia Hansel, Robert Brown, Gregory Diette, Richard Casaburi, Janos Porszasz, Hans Fischer, Matt Budoff, Amir Sharafkhaneh, Charles Trinh, Hirani Kamal, Roham Darvishi, Dennis Niewoehner, Tadashi Allen, Quentin Anderson, Kathryn Rice, Marilyn Foreman, Gloria Westney, Eugene Berkowitz, Russell Bowler, Adam Friedlander, David Lynch, Joyce Schroeder, John Newell, Gerard Criner, Victor Kim, Nathaniel Marchetti, Aditi Satti, A. James Mamary, Robert Steiner, Chandra Dass, William Bailey, Mark Dransfield, Hrudaya Nath, Joe Ramsdell, Paul Friedman, Geoffrey McLennan, Edwin J R van Beek, Brad Thompson, Dwight Look, Fernando Martinez, Mei Lan Han, Ella Kazerooni, Christine Wendt, Frank Sciurba, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Antonio Anzueto, Sandra Adams, Carlos Orozco, Mario Ruiz, Robert Jensen, Homayoon Farzadegan, Stacey Meyerer, Shivam Chandan, Samantha Bragan, James Murphy, Douglas Everett, Ruthie Knowles, Amber Powell, John Hokanson, Black-Shinn Jennifer Black-Shinn, Gregory Kinney, James Crapo, Edwin Silverman, Barry Make, Elizabeth Regan, Jonathan Samet, Sarah Moyle, Terri Beaty, Barbara Klanderman, Nan Laird, Christophe Lange, Michael Cho, Stephanie Santorico, John Hokanson, Dawn DeMeo, Nadia Hansel, Jacqueline Hetmanski, David Lynch, Joyce Schroeder, John Newell, John Reilly, Harvey Coxson, Philip Judy, Eric Hoffman, Raul San Jose Estepar, James Ross, Rebecca Leek, Jordan Zach, Alex Kluiber, Jered Sieren, Heather Baumhauer, Verity McArthur, Dzimitry Kazlouski, Andrew Allen

Research output: Contribution to journal › Article › peer-review

371 Scopus citations

Abstract

Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.

Original language	English (US)
Article number	127
Journal	Respiratory research
Volume	12
Issue number	1
DOIs	https://doi.org/10.1186/1465-9921-12-127
State	Published - Sep 27 2011

Bibliographical note

Publisher Copyright:
© 2011 Hardin et al; licensee BioMed Central Ltd.

Keywords

Airway hyperresponsiveness
Asthma
Chronic obstructive pulmonary disease
Emphysema
Exacerbation
Gas-trapping

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1465-9921-12-127

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Hardin, M., Silverman, E. K., Barr, R. G., Hansel, N. N., Schroeder, J. D., Make, B. J., Crapo, J. D., Hersh, C. P., Curtis, J., Kazerooni, E., Hanania, N., Alapat, P., Bandi, V., Guntupalli, K., Guy, E., Mallampalli, A., Trinh, C., Atik, M., DeMeo, D., ... Allen, A. (2011). The clinical features of the overlap between COPD and asthma. Respiratory research, 12(1), Article 127. https://doi.org/10.1186/1465-9921-12-127

Hardin, M, Silverman, EK, Barr, RG, Hansel, NN, Schroeder, JD, Make, BJ, Crapo, JD, Hersh, CP, Curtis, J, Kazerooni, E, Hanania, N, Alapat, P, Bandi, V, Guntupalli, K, Guy, E, Mallampalli, A, Trinh, C, Atik, M, DeMeo, D, Hersh, C, Washko, G, Jacobson, F, Graham Barr, R, Thomashow, B, Austin, J, Neil MacIntyre, M, Washington, L, Page McAdams, H, Rosiello, R, Bresnahan, T, McEvoy, C, Tashjian, J, Wise, R, Hansel, N, Brown, R, Diette, G, Casaburi, R, Porszasz, J, Fischer, H, Budoff, M, Sharafkhaneh, A, Trinh, C, Kamal, H, Darvishi, R, Niewoehner, D, Allen, T, Anderson, Q, Rice, K, Foreman, M, Westney, G, Berkowitz, E, Bowler, R, Friedlander, A, Lynch, D, Schroeder, J, Newell, J, Criner, G, Kim, V, Marchetti, N, Satti, A, James Mamary, A, Steiner, R, Dass, C, Bailey, W, Dransfield, M, Nath, H, Ramsdell, J, Friedman, P, McLennan, G, van Beek, EJR, Thompson, B, Look, D, Martinez, F, Han, ML, Kazerooni, E, Wendt, C, Sciurba, F, Weissfeld, J, Fuhrman, C, Bon, J, Anzueto, A, Adams, S, Orozco, C, Ruiz, M, Jensen, R, Farzadegan, H, Meyerer, S, Chandan, S, Bragan, S, Murphy, J, Everett, D, Knowles, R, Powell, A, Hokanson, J, Jennifer Black-Shinn, B-S, Kinney, G, Crapo, J, Silverman, E, Make, B, Regan, E, Samet, J, Moyle, S, Beaty, T, Klanderman, B, Laird, N, Lange, C, Cho, M, Santorico, S, Hokanson, J, DeMeo, D, Hansel, N, Hetmanski, J, Lynch, D, Schroeder, J, Newell, J, Reilly, J, Coxson, H, Judy, P, Hoffman, E, San Jose Estepar, R, Ross, J, Leek, R, Zach, J, Kluiber, A, Sieren, J, Baumhauer, H, McArthur, V, Kazlouski, D & Allen, A 2011, 'The clinical features of the overlap between COPD and asthma', Respiratory research, vol. 12, no. 1, 127. https://doi.org/10.1186/1465-9921-12-127

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abstract = "Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.",

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note = "Publisher Copyright: {\textcopyright} 2011 Hardin et al; licensee BioMed Central Ltd.",

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doi = "10.1186/1465-9921-12-127",

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AU - Silverman, Edwin K.

AU - Barr, R. Graham

AU - Hansel, Nadia N.

AU - Schroeder, Joyce D.

AU - Make, Barry J.

AU - Crapo, James D.

AU - Hersh, Craig P.

AU - Curtis, Jeffrey

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AU - Hanania, Nicola

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AU - Bandi, Venkata

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AU - Jacobson, Francine

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AU - Thomashow, Byron

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AU - Neil MacIntyre, MacIntyre

AU - Washington, Lacey

AU - Page McAdams, H.

AU - Rosiello, Richard

AU - Bresnahan, Timothy

AU - McEvoy, Charlene

AU - Tashjian, Joseph

AU - Wise, Robert

AU - Hansel, Nadia

AU - Brown, Robert

AU - Diette, Gregory

AU - Casaburi, Richard

AU - Porszasz, Janos

AU - Fischer, Hans

AU - Budoff, Matt

AU - Sharafkhaneh, Amir

AU - Trinh, Charles

AU - Kamal, Hirani

AU - Darvishi, Roham

AU - Niewoehner, Dennis

AU - Allen, Tadashi

AU - Anderson, Quentin

AU - Rice, Kathryn

AU - Foreman, Marilyn

AU - Westney, Gloria

AU - Berkowitz, Eugene

AU - Bowler, Russell

AU - Friedlander, Adam

AU - Lynch, David

AU - Schroeder, Joyce

AU - Newell, John

AU - Criner, Gerard

AU - Kim, Victor

AU - Marchetti, Nathaniel

AU - Satti, Aditi

AU - James Mamary, A.

AU - Steiner, Robert

AU - Dass, Chandra

AU - Bailey, William

AU - Dransfield, Mark

AU - Nath, Hrudaya

AU - Ramsdell, Joe

AU - Friedman, Paul

AU - McLennan, Geoffrey

AU - van Beek, Edwin J R

AU - Thompson, Brad

AU - Look, Dwight

AU - Martinez, Fernando

AU - Han, Mei Lan

AU - Kazerooni, Ella

AU - Wendt, Christine

AU - Sciurba, Frank

AU - Weissfeld, Joel

AU - Fuhrman, Carl

AU - Bon, Jessica

AU - Anzueto, Antonio

AU - Adams, Sandra

AU - Orozco, Carlos

AU - Ruiz, Mario

AU - Jensen, Robert

AU - Farzadegan, Homayoon

AU - Meyerer, Stacey

AU - Chandan, Shivam

AU - Bragan, Samantha

AU - Murphy, James

AU - Everett, Douglas

AU - Knowles, Ruthie

AU - Powell, Amber

AU - Hokanson, John

AU - Jennifer Black-Shinn, Black-Shinn

AU - Kinney, Gregory

AU - Crapo, James

AU - Silverman, Edwin

AU - Make, Barry

AU - Regan, Elizabeth

AU - Samet, Jonathan

AU - Moyle, Sarah

AU - Beaty, Terri

AU - Klanderman, Barbara

AU - Laird, Nan

AU - Lange, Christophe

AU - Cho, Michael

AU - Santorico, Stephanie

AU - Hokanson, John

AU - DeMeo, Dawn

AU - Hansel, Nadia

AU - Hetmanski, Jacqueline

AU - Lynch, David

AU - Schroeder, Joyce

AU - Newell, John

AU - Reilly, John

AU - Coxson, Harvey

AU - Judy, Philip

AU - Hoffman, Eric

AU - San Jose Estepar, Raul

AU - Ross, James

AU - Leek, Rebecca

AU - Zach, Jordan

AU - Kluiber, Alex

AU - Sieren, Jered

AU - Baumhauer, Heather

AU - McArthur, Verity

AU - Kazlouski, Dzimitry

AU - Allen, Andrew

PY - 2011/9/27

Y1 - 2011/9/27

N2 - Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.

AB - Background: The coexistence of COPD and asthma is widely recognized but has not been well described. This study characterizes clinical features, spirometry, and chest CT scans of smoking subjects with both COPD and asthma. Methods: We performed a cross-sectional study comparing subjects with COPD and asthma to subjects with COPD alone in the COPDGene Study. Results: 119 (13%) of 915 subjects with COPD reported a history of physician-diagnosed asthma. These subjects were younger (61.3 vs 64.7 years old, p = 0.0001) with lower lifetime smoking intensity (43.7 vs 55.1 pack years, p = 0.0001). More African-Americans reported a history of asthma (33.6% vs 15.6%, p < 0.0001). Subjects with COPD and asthma demonstrated worse disease-related quality of life, were more likely to have had a severe COPD exacerbation in the past year, and were more likely to experience frequent exacerbations (OR 3.55 [2.19, 5.75], p < 0.0001). Subjects with COPD and asthma demonstrated greater gas-trapping on chest CT. There were no differences in spirometry or CT measurements of emphysema or airway wall thickness. Conclusion: Subjects with COPD and asthma represent a relevant clinical population, with worse health-related quality of life. They experience more frequent and severe respiratory exacerbations despite younger age and reduced lifetime smoking history. Trial registration: ClinicalTrials.gov: NCT00608764.

KW - Airway hyperresponsiveness

KW - Asthma

KW - Chronic obstructive pulmonary disease

KW - Emphysema

KW - Exacerbation

KW - Gas-trapping

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SN - 1465-9921

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JO - Respiratory research

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ER -

The clinical features of the overlap between COPD and asthma

Abstract

Bibliographical note

Keywords

UN SDGs

Access

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