Abstract
Human paraoxonase 1 (hPON-1) is a protein that has been studied in relation to its antioxidant and anti-atherosclerotic properties. Despite extensive studies, the molecular mechanisms responsible for its functional properties remain unclear. During the last decade, a new partner of hPON-1 has been identifi ed. Hidden for a long time because of a similar molecular weight with hPON-1, this protein, termed human phosphate-binding protein (HPBP), may contribute to the biological functions of hPON-1. Belonging to the DING protein, a sub-family of phosphate binding proteins (PBP or pstS), HPBP stabilizes hPON-1 and might prevent calcifi cation of arteries in case of advance atherosclerosis. The role of other DING proteins in some calcifi cation processes (i.e. nephrolithiasis) and the identifi cation of HPBP in the atheroma plaque support this hypothesis. Nevertheless, the relevance of hPON-1/HPBP as well as the molecular determinants in atherosclerosis remains to be elucidated.
Original language | English (US) |
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Title of host publication | Oxidative Stress and Inflammation in Non-Communicable Diseases - Molecular Mechanisms and Perspectives in Therapeutics |
Publisher | Springer New York LLC |
Pages | 27-32 |
Number of pages | 6 |
ISBN (Print) | 9783319073194 |
DOIs | |
State | Published - 2014 |
Publication series
Name | Advances in Experimental Medicine and Biology |
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Volume | 824 |
ISSN (Print) | 0065-2598 |
ISSN (Electronic) | 2214-8019 |
Bibliographical note
Publisher Copyright:© Springer International Publishing Switzerland 2014.
Keywords
- DING proteins
- HPBP
- Infl ammation
- Phosphate-binding proteins