TY - JOUR
T1 - The Effect of Paraldehyde on Intravenous Tubing Sets
AU - Schallinger, Luke E.
AU - Uden, Donald L.
PY - 1989
Y1 - 1989
N2 - Paraldehyde is used in the treatment of status epilepticus, alcohol withdrawal, and delerium tremens. Because it is a solvent, concerns have been raised about infusing it through plastic intravenous tubing sets. In a three‐phase study, 4% paraldehyde in 5% dextrose solution was analyzed over 24 hours for photodegradation, adsorption to polyvinylchloride‐ (PVC) and polyethylene‐ (PE) lined intravenous tubing, and the presence of di(2‐ethylhexyl) phthalate (DEHP). Paraldehyde and DEHP samples were quantified by gas chromatography, and DEHP was confirmed by mass spectral analysis. On exposure to light for 24 hours, the concentration of paraldehyde decreased from 100 to 97%. This decrease is statistically significant but clinically insignificant. A 24‐hour continuous infusion of paraldehyde through the two types of tubing revealed a decrease in concentration attributable to adsorption of 4% with PE and 13% with PVC tubing at 2 hours. In addition, there was no appreciable leaching of DEHP over 24 hours with either type of tubing. Concerns about paraldehyde's light instability and effects on tubing integrity appear to be unwarranted with commercially available intravenous administration sets. 1989 Pharmacotherapy Publications Inc.
AB - Paraldehyde is used in the treatment of status epilepticus, alcohol withdrawal, and delerium tremens. Because it is a solvent, concerns have been raised about infusing it through plastic intravenous tubing sets. In a three‐phase study, 4% paraldehyde in 5% dextrose solution was analyzed over 24 hours for photodegradation, adsorption to polyvinylchloride‐ (PVC) and polyethylene‐ (PE) lined intravenous tubing, and the presence of di(2‐ethylhexyl) phthalate (DEHP). Paraldehyde and DEHP samples were quantified by gas chromatography, and DEHP was confirmed by mass spectral analysis. On exposure to light for 24 hours, the concentration of paraldehyde decreased from 100 to 97%. This decrease is statistically significant but clinically insignificant. A 24‐hour continuous infusion of paraldehyde through the two types of tubing revealed a decrease in concentration attributable to adsorption of 4% with PE and 13% with PVC tubing at 2 hours. In addition, there was no appreciable leaching of DEHP over 24 hours with either type of tubing. Concerns about paraldehyde's light instability and effects on tubing integrity appear to be unwarranted with commercially available intravenous administration sets. 1989 Pharmacotherapy Publications Inc.
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U2 - 10.1002/j.1875-9114.1989.tb04153.x
DO - 10.1002/j.1875-9114.1989.tb04153.x
M3 - Article
C2 - 2616353
AN - SCOPUS:0024791566
SN - 0277-0008
VL - 9
SP - 381
EP - 385
JO - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
JF - Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
IS - 6
ER -